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Filing Details

Accession Number:: 0000874015-12-000030
Form Type:: 4
Zero Holdings:: No
Publication Time:: 2012-06-25 20:56:56
Reporting Period:: 2012-06-25

Filing Date:: 2012-06-25
Accepted Time:: 2012-06-25 20:56:56
SEC Url:: Form 4 Filing

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1181548	R Spencer Berthelsen	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010		Yes	No	No	No

Reported Non-Derivative Transactions

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Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2012-06-25	300	$8.15	29,600	No	4	M	Direct
Common Stock	Disposition	2012-06-25	300	$11.48	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	200	$8.15	29,500	No	4	M	Direct
Common Stock	Disposition	2012-06-25	200	$11.49	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	300	$8.15	29,600	No	4	M	Direct
Common Stock	Disposition	2012-06-25	300	$11.49	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	200	$8.15	29,500	No	4	M	Direct
Common Stock	Disposition	2012-06-25	200	$11.50	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	500	$8.15	29,800	No	4	M	Direct
Common Stock	Disposition	2012-06-25	500	$11.51	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	228	$8.15	29,528	No	4	M	Direct
Common Stock	Disposition	2012-06-25	228	$11.53	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	205	$8.15	29,505	No	4	M	Direct
Common Stock	Disposition	2012-06-25	205	$11.54	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	495	$8.15	29,795	No	4	M	Direct
Common Stock	Disposition	2012-06-25	495	$11.55	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	700	$8.15	30,000	No	4	M	Direct
Common Stock	Disposition	2012-06-25	700	$11.56	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	3,500	$8.15	32,800	No	4	M	Direct
Common Stock	Disposition	2012-06-25	3,500	$11.58	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	1,500	$8.15	30,800	No	4	M	Direct
Common Stock	Disposition	2012-06-25	1,500	$11.58	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	100	$8.15	29,400	No	4	M	Direct
Common Stock	Disposition	2012-06-25	100	$11.59	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	1,600	$8.15	30,900	No	4	M	Direct
Common Stock	Disposition	2012-06-25	1,600	$11.60	29,300	No	4	S	Direct
Common Stock	Acquisiton	2012-06-25	172	$8.15	29,472	No	4	M	Direct
Common Stock	Disposition	2012-06-25	172	$11.62	29,300	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

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Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Director Stock Option (right to buy)	Disposition	2012-06-25	10,000	$0.00	10,000	$8.15

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0	2006-07-01	2012-06-30	No	4	M	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	70	Indirect	By Daughter

Footnotes

Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/12. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/12.