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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1113481	Medicines Co	MDCO	Pharmaceutical Preparations (2834)	043324394

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1277478	Glenn Sblendorio	8 Sylvan Way Parsippany NJ 07054	Executive Vp & Cfo	Yes	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2012-02-21	1,505	$20.94	65,097	No	4	S	Direct
Common Stock	Disposition	2012-02-21	833	$20.94	64,264	No	4	S	Direct
Common Stock	Disposition	2012-02-21	1,781	$20.94	62,483	No	4	S	Direct
Common Stock	Acquisiton	2012-02-21	625	$7.31	63,108	No	4	M	Direct
Common Stock	Disposition	2012-02-21	625	$21.03	62,483	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Option(right to buy)	Disposition	2012-02-21	625	$7.31	625	$7.31

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
16,250		2020-02-19	No	4	M	Direct

Footnotes

Represents the number of shares sold to cover the tax expense associated with the vesting of restricted shares held by Mr. Sblendorio pursuant to his Restricted Stock Agreements with the Company.
As of 2/21/2012, the original grant (30,000 shares granted on 2/19/2010) was vested with respect to 15,000 of the shares covered thereby and the remaining 15,000 shares covered by this option vest in equal monthly installments ending on 2/19/2014. After the exercise of the options reported hereby, as of 2/21/2012, 1,250 of the shares covered by the option were vested but not exercised.
The common stock sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 program adopted by Mr. Sblendorio on February 18, 2011.