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Filing Details

Accession Number:: 0000874015-11-000030
Form Type:: 4
Zero Holdings:: No
Publication Time:: 2011-12-20 21:05:54
Reporting Period:: 2011-12-16

Filing Date:: 2011-12-20
Accepted Time:: 2011-12-20 21:05:54
SEC Url:: Form 4 Filing

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1073385	Lynne B Parshall	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Director, Coo	Yes	Yes	No	No

Reported Non-Derivative Transactions

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Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2011-12-16	2,000	$5.80	3,985	No	4	M	Direct
Common Stock	Disposition	2011-12-16	2,000	$6.79	1,985	No	4	S	Direct
Common Stock	Acquisiton	2011-12-19	2,000	$5.80	2,000	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-16	2,000	$6.79	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2011-12-16	2,000	$5.80	2,000	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-16	2,000	$6.79	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2011-12-19	2,054	$5.80	4,039	No	4	M	Direct
Common Stock	Disposition	2011-12-19	2,054	$6.82	1,985	No	4	S	Direct
Common Stock	Acquisiton	2011-12-19	246	$5.80	2,231	No	4	M	Direct
Common Stock	Disposition	2011-12-19	246	$6.90	1,985	No	4	S	Direct
Common Stock	Acquisiton	2011-12-19	2,054	$5.80	2,054	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-19	2,054	$6.82	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2011-12-19	246	$5.80	246	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-19	246	$6.90	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2011-12-20	2,900	$5.80	4,885	No	4	M	Direct
Common Stock	Disposition	2011-12-20	2,900	$6.82	1,985	No	4	S	Direct
Common Stock	Acquisiton	2011-12-20	700	$5.80	2,685	No	4	M	Direct
Common Stock	Disposition	2011-12-20	700	$6.92	1,985	No	4	S	Direct
Common Stock	Acquisiton	2011-12-20	700	$5.80	700	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-20	700	$6.92	0	No	4	S	Indirect	Bu daughter
Common Stock	Acquisiton	2011-12-20	2,800	$5.80	2,800	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-20	2,800	$6.82	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2011-12-20	700	$5.80	700	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-20	700	$6.92	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2011-12-20	2,800	$5.80	2,800	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-20	2,800	$6.82	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2011-12-19	246	$5.80	246	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-19	246	$6.90	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2011-12-19	2,054	$580.00	2,054	No	4	M	Indirect	By daughter
Common Stock	Disposition	2011-12-19	2,054	$6.82	0	No	4	S	Indirect	By daughter

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Indirect	By daughter
No	4	S	Indirect	Bu daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter

Reported Derivative Transactions

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Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Disposition	2011-12-16	2,000	$0.00	2,000	$5.80
Common Stock	Employee Stock Option (right to buy)	Disposition	2011-12-16	2,000	$0.00	2,000	$5.80
Common Stock	Employee Stock Option (right to buy)	Disposition	2011-12-16	2,000	$0.00	2,000	$5.80
Common Stock	Employee Stock Option (right to buy)	Disposition	2011-12-19	2,300	$0.00	2,300	$5.80
Common Stock	Employee Stock Option (right to buy)	Disposition	2011-12-19	2,300	$0.00	2,300	$5.80
Common Stock	Employee Stock Option (right to buy)	Disposition	2011-12-19	2,300	$0.00	2,300	$5.80
Common Stock	Employee Stock Option (right to buy)	Disposition	2011-12-20	3,600	$0.00	3,600	$5.80
Common Stock	Employee Stock Option (right to buy)	Disposition	2011-12-20	3,500	$0.00	3,500	$5.80
Common Stock	Employee Stock Option (right to buy)	Disposition	2011-12-20	3,500	$0.00	3,500	$5.80

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
8,263	2009-01-03	2012-01-02	No	4	M	Direct
8,000	2009-01-03	2012-01-02	No	4	M	Indirect
8,000	2009-01-03	2012-01-02	No	4	M	Indirect
5,963	2009-01-03	2012-01-02	No	4	M	Direct
5,700	2009-01-03	2012-01-02	No	4	M	Indirect
5,700	2009-01-03	2012-01-02	No	4	M	Indirect
2,363	2009-01-03	2012-01-02	No	4	M	Direct
2,200	2009-01-03	2012-01-02	No	4	M	Indirect
2,200	2009-01-03	2012-01-02	No	4	M	Indirect

Footnotes

Acquired as a result of exercising a stock option that was scheduled to expire on 1/2/12. The purchase and sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 10/21/11.
Acquired as a result of exercising a stock option that was scheduled to expire on 1/2/12. The purchase and sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person's daughter on 10/21/11.