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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1683553	Spruce Biosciences Inc.	SPRB	Pharmaceutical Preparations (2834)	812154263

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1780235	Niall O'donnell	C/O Rivervest Venture Partners 101 S. Hanley Rd., Ste. 1850 St. Louis MO 63105		Yes	No	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2023-02-16	630,400	$3.17	1,326,305	No	4	P	Indirect	By RiverVest Venture Fund IV, L.P.

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	P	Indirect	By RiverVest Venture Fund IV, L.P.

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Common Stock Warrant (Right to Buy)	Acquisiton	2023-02-16	472,800	$0.00	472,800	$3.96

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
472,800	2023-02-16	2028-02-16	No	4	P	Indirect

Footnotes

The shares were purchased in the Issuer's private offering.
Represents the combined purchase price of $3.17 for Common Stock and Warrants acquired from Issuer in a private offering.
RiverVest Venture Partners IV, L.P. is the general partner of RiverVest Venture Fund IV, L.P. The Reporting Person is a manager of RiverVest Venture Partners IV, LLC, the sole general partner of RiverVest Venture Partners IV, L.P., and as a result may be deemed to share dispositive voting and investment power with respect to the shares held by RiverVest Venture Partners IV, L.P. The Reporting Person disclaims beneficial ownership of all shares held by RiverVest Venture Partners IV, L.P. except to the extent of his pecuniary interests therein.
The warrant was purchased in the Issuer's private offering.