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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1789815	Ourania Tatsis	C/O Vertex Pharmaceuticals Incorporated 50 Northern Avenue Boston MA 02210	Evp, Chief Reg. & Quality Off.	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2023-02-10	1,377	$294.33	69,035	No	4	F	Direct
Common Stock	Disposition	2023-02-13	2,995	$298.26	66,040	No	4	F	Direct
Common Stock	Disposition	2023-02-13	2	$295.84	66,038	No	4	S	Direct
Common Stock	Disposition	2023-02-13	78	$298.11	65,960	No	4	S	Direct
Common Stock	Disposition	2023-02-13	120	$298.98	65,840	No	4	S	Direct
Common Stock	Disposition	2023-02-13	64	$299.88	65,776	No	4	S	Direct
Common Stock	Disposition	2023-02-13	11	$300.79	65,765	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	F	Direct
No	4	F	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct

Footnotes

Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.
Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Open market sales reported on this line occurred at a weighted average price of $298.11 (range $297.51 to $298.50).
Open market sales reported on this line occurred at a weighted average price of $298.98 (range $298.53 to $299.50).
Open market sales reported on this line occurred at a weighted average price of $299.88 (range $299.62 to $300.53).