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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1937653	Zymeworks Inc.	ZYME	()	DE

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1587114	Ecor1 Capital, Llc	357 Tehama Street #3 San Francisco CA 94103		No	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2023-01-19	144,100	$9.49	9,724,073	No	4	P	Indirect	See Note 1
Common Stock	Acquisiton	2023-01-20	163,400	$9.88	9,887,473	No	4	P	Indirect	See Note 1

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	P	Indirect	See Note 1
No	4	P	Indirect	See Note 1

Footnotes

The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.
Qualified Fund purchased 135,728 shares of the Common Stock acquired in this transaction.
After this transaction, Qualified Fund directly owned 9,158,256 shares of Common Stock.
Qualified Fund purchased 153,906 shares of the Common Stock acquired in this transaction.
After this transaction, Qualified Fund directly owned 9,312,162 shares of Common Stock.