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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
944809	Opko Health Inc.	OPK	()	4

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
898860	Al Et Md Phillip Frost	Opko Health, Inc. 4400 Biscayne Blvd. Miami FL 33137	Ceo & Chairman	Yes	Yes	Yes	No
1380896	Trust Investments Gamma Frost	4400 Biscayne Blvd. Miami FL 33137		No	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2022-10-27	600	$1.80	198,232,294	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2022-10-27	30,723	$1.81	198,263,017	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2022-10-27	190	$1.81	198,263,207	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2022-10-27	925	$1.82	198,264,132	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2022-10-27	200	$1.82	198,264,332	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2022-10-27	23,875	$1.82	198,288,207	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2022-10-27	3,600	$1.83	198,291,807	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2022-10-27	4,900	$1.83	198,296,707	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2022-10-27	20,600	$1.83	198,317,307	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2022-10-27	14,387	$1.84	198,331,694	No	4	P	Indirect	See Footnote

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	3,068,951	Direct
Common Stock	30,127,177	Indirect	See Footnote

Footnotes

The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.