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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1789815	Ourania Tatsis	C/O Vertex Pharmaceuticals Incorporated 50 Northern Avenue Boston MA 02210	Evp, Chief Reg. & Quality Off.	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2022-08-09	292	$297.54	47,198	No	4	S	Direct
Common Stock	Disposition	2022-08-09	679	$298.77	46,519	No	4	S	Direct
Common Stock	Disposition	2022-08-09	283	$299.79	46,236	No	4	S	Direct
Common Stock	Disposition	2022-08-09	72	$300.64	46,164	No	4	S	Direct
Common Stock	Disposition	2022-08-09	74	$301.67	46,090	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct

Footnotes

Includes 134 shares previously purchased under the issuer's Employee Stock Purchase Plan.
Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.
Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Open market sales reported on this line occurred at a weighted average price of $297.54 (range $297.00 to $297.80).
Open market sales reported on this line occurred at a weighted average price of $298.77 (range $298.29 to $299.19).
Open market sales reported on this line occurred at a weighted average price of $299.79 (range $299.44 to $300.33).