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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1856587	Kristen Ambrose	C/O Vertex Pharmaceuticals Incorporated 50 Northern Avenue Boston MA 02210	Svp & Chief Accounting Officer	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2022-04-25	60	$267.37	3,763	No	4	S	Direct
Common Stock	Disposition	2022-04-25	80	$268.46	3,683	No	4	S	Direct
Common Stock	Disposition	2022-04-25	83	$269.51	3,600	No	4	S	Direct
Common Stock	Disposition	2022-04-25	104	$271.68	3,496	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct

Footnotes

Transaction made pursuant to Ms. Ambrose's company approved trading plan under Rule 10b5-1.
Ms. Ambrose undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Open market sales reported on this line occurred at a weighted average price of $267.37 (range $266.86 to $267.85).
Open market sales reported on this line occurred at a weighted average price of $268.46 (range $268.05 to $268.86).
Open market sales reported on this line occurred at a weighted average price of $269.51 (range $269.12 to $269.90).
Open market sales reported on this line occurred at a weighted average price of $271.68 (range $271.25 to $272.23).