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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1789815	Ourania Tatsis	C/O Vertex Pharmaceuticals Incorporated 50 Northern Avenue Boston MA 02210	Evp, Chief Reg. & Quality Off.	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2022-02-17	4,114	$232.51	53,623	No	4	F	Direct
Common Stock	Disposition	2022-02-18	218	$229.52	53,405	No	4	S	Direct
Common Stock	Disposition	2022-02-18	101	$230.42	53,304	No	4	S	Direct
Common Stock	Disposition	2022-02-18	80	$232.04	53,224	No	4	S	Direct
Common Stock	Disposition	2022-02-18	120	$233.48	53,104	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	F	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct
No	4	S	Direct

Footnotes

Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1.
Open market sales reported on this line occurred at a weighted average price of $229.52 (range $229.05 to $229.97).
Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Open market sales reported on this line occurred at a weighted average price of $230.42 (range $230.05 to $230.75).
Open market sales reported on this line occurred at a weighted average price of $232.04 (range $231.89 to $232.13).
Open market sales reported on this line occurred at a weighted average price of $233.48 (range $233.18 to $233.73).