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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1701108	Spero Therapeutics Inc.	SPRO	()	DE

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1491371	Aquilo Capital, L.p.	One Letterman Drive, Suite D4900 Building D, The Presidio San Francisco CA 94129		No	No	Yes	No
1591986	Aquilo Capital Management, Llc	One Letterman Drive Suite D4900, Building D San Francisco CA 94129		No	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock, $0.001 Par Value	Acquisiton	2021-12-29	75,493	$14.64	4,789,181	No	4	P	Indirect	See footnotes
Common Stock, $0.001 Par Value	Acquisiton	2021-12-30	50,000	$15.77	4,839,181	No	4	P	Indirect	See Footnotes
Common Stock, $0.001 Par Value	Acquisiton	2021-12-31	125,000	$15.75	4,964,181	No	4	P	Indirect	See Footnotes

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	P	Indirect	See footnotes
No	4	P	Indirect	See Footnotes
No	4	P	Indirect	See Footnotes

Footnotes

The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.
Aquilo Capital, LP owns only 3,378,881 of the 4,789,181 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 75,493 shares purchased in this transaction on 12/29/2021.
Aquilo Capital, LP owns only 3,378,881 of the 4,839,181 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 50,000 shares purchased in this transaction on 12/30/2021.
Aquilo Capital, LP owns only 3,378,881 of the 4,964,181 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 125,000 shares purchased in this transaction on 12/31/2021.