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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1559053	Prothena Corp Public Ltd Co	PRTA	Pharmaceutical Preparations (2834)	000000000

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1587114	Ecor1 Capital, Llc	357 Tehama Street #3 San Francisco CA 94103		No	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Ordinary Shares	Acquisiton	2021-02-23	44,400	$21.05	10,148,480	No	4	P	Indirect	See Note 1
Ordinary Shares	Acquisiton	2021-02-24	10,800	$22.02	10,159,280	No	4	P	Indirect	See Note 1

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	P	Indirect	See Note 1
No	4	P	Indirect	See Note 1

Footnotes

The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the Funds, and Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein.
Qualified Fund purchased 37,274 of the Ordinary Shares purchased in this transaction. After this transaction, Qualified Fund owned 8,519,649 Ordinary Shares.
Qualified Fund purchased 9,067 of the Ordinary Shares purchased in this transaction. After this transaction, Qualified Fund owned 8,528,716 Ordinary Shares.