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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1408443	Milestone Pharmaceuticals Inc.	MIST	Pharmaceutical Preparations (2834)	000000000

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1493215	Rtw Investments, Lp	412 West 15Th Street, Floor 9 New York NY 10011		No	No	Yes	No
1493280	Roderick Wong	C/O Rtw Investments, Lp 412 West 15Th Street, Floor 9 New York NY 10011		No	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Shares	Acquisiton	2019-12-30	1,333	$15.48	3,936,826	No	4	P	Indirect	By RTW
Common Shares	Acquisiton	2019-12-31	21,438	$15.50	3,958,264	No	4	P	Indirect	By RTW

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	P	Indirect	By RTW
No	4	P	Indirect	By RTW

Footnotes

This transaction was executed in multiple trades at prices ranging from $15.4350 to $15.4958. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the full information regarding the number of shares and prices at which the transaction was effected.
The securities reported herein may be deemed beneficially owned by each of: (i) RTW Investments, LP ("RTW"), which is deemed the beneficial owner of shares held by RTW Master Fund, Ltd., RTW Venture Fund Limited and RTW Innovation Master Fund, Ltd. (the "Funds"), which are investment funds managed by RTW, and (ii) Roderick Wong, M.D who serves as the Managing Partner and Chief Investment Officer of RTW. Dr. Wong exercises voting and dispositive control over the securities held by RTW and is therefore deemed to be a beneficial owner of securities owned or controlled by RTW. Each of RTW and Dr. Wong disclaim beneficial ownership of the reported securities held by the Funds, except to the extent of its or his pecuniary interest therein.