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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
944809	Opko Health Inc.	OPK	Pharmaceutical Preparations (2834)	752402409

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1188834	D Ph Jane Hsiao	Opko Health, Inc. 4400 Biscayne Blvd. Miami FL 33137	Vice Chairman & Cto	Yes	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Disposition	2011-12-21	831,052	$0.00	24,455,147	No	4	G	Direct
Common Stock	Acquisiton	2014-01-31	10,000	$7.96	24,465,147	No	4	P	Direct
Common Stock	Acquisiton	2012-07-27	20,000	$4.30	4,697,404	No	4	P	Indirect	See Footnote
Common Stock	Acquisiton	2012-07-30	30,000	$4.35	4,727,404	No	4	P	Indirect	See Footnote
Common Stock	Disposition	2018-12-13	1,000,000	$0.00	0	No	5	G	Indirect	See Footnote
Common Stock	Disposition	2018-12-13	1,000,000	$0.00	0	No	5	G	Indirect	See Footnote

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	G	Direct
No	4	P	Direct
No	4	P	Indirect	See Footnote
No	4	P	Indirect	See Footnote
No	5	G	Indirect	See Footnote
No	5	G	Indirect	See Footnote

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	20,091,062	Indirect	See Footnote

Footnotes

The securities are owned directly by Hsu Gamma Investment, L.P. Dr. Hsiao is the general partner of Hsu Gamma Investment, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose.
The securities are held by The Chin Hsiao Family Trust A, of which Jane H. Hsiao, Ph.D. is the trustee.
The securities are held by The Chin Hsiao Family Trust B, of which Jane H. Hsiao, Ph.D. is the trustee.
These securities are owned directly by The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose.