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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1503802	Karyopharm Therapeutics Inc.	KPTI	Pharmaceutical Preparations (2834)	263931704

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1588438	Sharon Shacham	C/O Karyopharm Therapeutics Inc. 85 Wells Avenue Newton MA 02459	President & Cso	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2017-12-07	10,000	$0.26	723,510	No	4	M	Direct
Common Stock	Disposition	2017-12-07	10,000	$10.39	713,510	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option (right to buy)	Disposition	2017-12-07	10,000	$0.00	10,000	$0.26

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
29,394		2021-12-13	No	4	M	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	512,143	Indirect	By Spouse
Common Stock	47,309	Indirect	By GRAT
Common Stock	47,309	Indirect	By Spouse's GRAT

Footnotes

These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
Reflects the contribution of 60,000 shares previously owned directly to the Sharon Shacham 2016 Qualified Annuity Interest Trust ("GRAT") on September 9, 2016 and the transfer of 12,691 shares from the GRAT to the reporting person on November 6, 2017.
Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $10.14 to $10.48, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
Reflects the contribution of 60,000 shares previously owned directly by the spouse of the reporting person to the Michael G. Kauffman 2016 Qualified Annuity Interest Trust ("Spouse's GRAT") on September 9, 2016 and the transfer of 12,691 shares from the Spouse's GRAT to the spouse of the reporting person on November 6, 2017.
These shares are held by the GRAT.
These shares are held by the Spouse's GRAT.
This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on December 12, 2012, and the remaining 75% vested in 36 equal monthly installments thereafter.