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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Ionis Pharmaceuticals Inc	IONS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1564926	R. Patrick O'neil	C/O Ionis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Svp, Legal & General Counsel	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2016-01-01	43	$47.71	6,302	No	5	J	Direct
Common Stock	Acquisiton	2016-01-04	152	$10.82	6,454	No	4	M	Direct
Common Stock	Disposition	2016-01-04	152	$61.10	6,302	No	4	S	Direct
Common Stock	Acquisiton	2016-01-04	848	$7.25	7,150	No	4	M	Direct
Common Stock	Disposition	2016-01-04	848	$61.10	6,302	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	5	J	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Acquisiton	2016-01-04	38,240	$0.00	38,240	$61.68
Common Stock	Employee Stock Option (right to buy)	Disposition	2016-01-04	152	$0.00	152	$10.82
Common Stock	Employee Stock Option (right to buy)	Disposition	2016-01-04	848	$0.00	848	$7.25

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
38,240	2017-01-04	2023-01-03	No	4	A	Direct
7,101	2014-01-02	2020-01-01	No	4	M	Direct
1,219	2016-01-03	2019-01-02	No	4	M	Direct

Footnotes

Reporting 43 shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2016. These 43 shares may not be sold until July 2, 2016.
Grant of 1/4/2016 to reporting person of stock options under the Ionis Pharmacueticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 1/4/2017. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 9,560 shares per year. Following this transaction, the option was exercisable as to 0 on 1/4/2016.
Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 9/21/2015.
Grant of 1/2/2013 to reporting person of stock options under the Ionis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/2014. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 3,925 shares per year. Following this transaction, the option was exercisable as to 3,176 on 1/4/2015.