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Filing Details

Accession Number:: 0000874015-15-000078
Form Type:: 4
Zero Holdings:: No
Publication Time:: 2015-10-05 19:14:12
Reporting Period:: 2015-10-01

Filing Date:: 2015-10-05
Accepted Time:: 2015-10-05 19:14:12
SEC Url:: Form 4 Filing

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1073385	Lynne B Parshall	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Coo & Secretary	Yes	Yes	No	No

Reported Non-Derivative Transactions

Show Other Fields >>

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2015-10-01	4,162	$7.25	12,305	No	4	M	Direct
Common Stock	Disposition	2015-10-01	4,162	$40.13	8,143	No	4	S	Direct
Common Stock	Acquisiton	2015-10-01	2,838	$14.69	10,981	No	4	M	Direct
Common Stock	Disposition	2015-10-01	2,838	$40.13	8,143	No	4	S	Direct
Common Stock	Acquisiton	2015-10-02	2,000	$14.69	10,143	No	4	M	Direct
Common Stock	Disposition	2015-10-02	2,000	$40.10	8,143	No	4	S	Direct
Common Stock	Acquisiton	2015-10-02	3,436	$14.69	11,579	No	4	M	Direct
Common Stock	Disposition	2015-10-02	3,436	$42.39	8,143	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

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Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Disposition	2015-10-01	4,162	$0.00	4,162	$7.25
Common Stock	Employee Stock Option (right to buy)	Disposition	2015-10-01	2,838	$0.00	2,838	$14.69
Common Stock	Employee Stock Option (right to buy)	Disposition	2015-10-02	5,436	$0.00	5,436	$14.69

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
12,865	2013-01-03	2019-01-02	No	4	M	Direct
34,790	2014-01-02	2020-01-29	No	4	M	Direct
29,354	2013-01-30	2020-01-29	No	4	M	Direct

Footnotes

Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 2/11/2015.
The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $39.80 to $40.75, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.
The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $42.00 to $42.70, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.
Grant of 1/3/2012 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2013. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 15,437 shares per year. Following this transaction, the option was exercisable as to 7,719 on 10/1/2015.
Grant of 1/30/2013 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/2014. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 15,570 shares per year. Following this transaction, the option was exercisable as to 14,030 on 10/1/2015.
Grant of 1/30/2013 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/2014. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 15,570 shares per year. Following this transaction, the option was exercisable as to 9,891 on 10/2/2015.