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Filing Details

Accession Number:: 0000874015-15-000025
Form Type:: 4
Zero Holdings:: No
Publication Time:: 2015-01-20 20:00:06
Reporting Period:: 2015-01-15

Filing Date:: 2015-01-20
Accepted Time:: 2015-01-20 20:00:06
SEC Url:: Form 4 Filing

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
897667	T Stanley Crooke	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Chairman And Ceo	Yes	Yes	No	No

Reported Non-Derivative Transactions

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Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2015-01-15	2,977	$0.00	9,918	No	4	M	Direct
Common Stock	Disposition	2015-01-16	1,574	$67.96	8,344	No	4	S	Direct
Common Stock	Acquisiton	2015-01-15	5,548	$0.00	13,892	No	4	M	Direct
Common Stock	Disposition	2015-01-16	2,933	$67.96	10,959	No	4	S	Direct
Common Stock	Acquisiton	2015-01-15	7,813	$0.00	18,772	No	4	M	Direct
Common Stock	Disposition	2015-01-16	4,130	$67.96	14,642	No	4	S	Direct
Common Stock	Acquisiton	2015-01-15	316	$0.00	943	No	4	M	Indirect	By wife
Common Stock	Disposition	2015-01-16	121	$67.96	822	No	4	S	Indirect	By wife
Common Stock	Acquisiton	2015-01-15	417	$0.00	1,239	No	4	M	Indirect	By wife
Common Stock	Disposition	2015-01-16	160	$67.96	1,079	No	4	S	Indirect	By wife
Common Stock	Acquisiton	2015-01-15	354	$0.00	1,433	No	4	M	Indirect	By wife
Common Stock	Disposition	2015-01-16	136	$67.96	1,297	No	4	S	Indirect	By wife

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Indirect	By wife
No	4	S	Indirect	By wife
No	4	M	Indirect	By wife
No	4	S	Indirect	By wife
No	4	M	Indirect	By wife
No	4	S	Indirect	By wife

Reported Derivative Transactions

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Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Restricted Stock Units	Acquisiton	2015-01-15	27,500	$0.00	27,500	$0.00
Common Stock	Restricted Stock Units	Acquisiton	2015-01-15	1,450	$0.00	1,450	$0.00
Common Stock	Restricted Stock Units	Disposition	2015-01-15	2,977	$0.00	2,977	$0.00
Common Stock	Restricted Stock Units	Disposition	2015-01-15	5,548	$0.00	5,548	$0.00
Common Stock	Restricted Stock Units	Disposition	2015-01-15	7,813	$0.00	7,813	$0.00
Common Stock	Restricted Stock Units	Disposition	2015-01-15	316	$0.00	316	$0.00
Common Stock	Restricted Stock Units	Disposition	2015-01-15	417	$0.00	417	$0.00
Common Stock	Restricted Stock Units	Disposition	2015-01-15	354	$0.00	354	$0.00

Remaning Holdings	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
27,500	No	4	A	Direct
1,450	No	4	A	Indirect
2,977	No	4	M	Direct
11,094	No	4	M	Direct
23,437	No	4	M	Direct
316	No	4	M	Indirect
832	No	4	M	Indirect
1,062	No	4	M	Indirect

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	725,391	Indirect	By trust

Footnotes

Acquired pursuant to vesting and release of shares pursuant to a RSU award granted on January 15, 2012.
The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2012.
Acquired pursuant to vesting and release of shares pursuant to a RSU award granted on January 30, 2013.
The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 30, 2013.
Acquired pursuant to vesting and release of shares pursuant to a RSU award granted on January 15, 2014.
The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2014.
Acquired pursuant to vesting and release of shares pursuant to a RSU award granted on January 15, 2013.
The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2013.
Each Restricted Stock Unit represents a contingent right to receive one share of Isis common stock, or its equivalent cash value.
Grant 1/15/2015 to reporting person of Restricted Stock Units under the Isis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on January 15, 2016. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2019. The RSU is vested as to 0 shares on January 15, 2015.
Grant 1/15/2015 to reporting person's wife of Restricted Stock Units under the Isis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on January 15, 2016. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2019. The RSU is vested as to 0 shares on January 15, 2015.
Restricted Stock Unit Award granted on January 15, 2012. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2013. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2016.
Restricted Stock Unit Award granted on January 30, 2013. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2014. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2017.
Restricted Stock Unit Award granted on January 15, 2014. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2015. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2018.
Restricted Stock Unit Award granted on January 15, 2013. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2014. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2017.