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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1347178	Vanda Pharmaceuticals Inc.	VNDA	Pharmaceutical Preparations (2834)	030491827

Insiders

Cik	Name	Reported Address	Director	Officer	Large Shareholder	Other
1009258	Deerfield Management Co	780 Third Avenue, 37Th Floor New York NY 10017	No	No	Yes	Yes
1010823	L.p. Mgmt Deerfield	780 Third Avenue, 37Th Floor New York NY 10017	No	No	Yes	Yes
1301041	Deerfield Partners, Lp	780 Third Avenue, 37Th Floor New York NY 10017	No	No	Yes	Yes
1352546	E James Flynn	780 Third Avenue, 37Th Floor New York NY 10017	No	No	Yes	Yes
1565089	Deerfield International Master Fund, L.p.	780 3Rd Avenue 37Th Floor New York NY 10017	No	No	Yes	Yes

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2014-12-23	11,100	$14.23	1,285,881	No	4	P	Indirect	Through Deerfield Partners, L.P.
Common Stock	Acquisiton	2014-12-23	13,900	$14.23	1,598,601	No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
Common Stock	Acquisiton	2014-12-23	13,320	$14.48	1,299,201	No	4	P	Indirect	Through Deerfield Partners, L.P.
Common Stock	Acquisiton	2014-12-23	16,680	$14.48	1,615,281	No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
Common Stock	Acquisiton	2014-12-23	11,100	$14.50	1,310,301	No	4	P	Indirect	Through Deerfield Partners, L.P.
Common Stock	Acquisiton	2014-12-23	13,900	$14.50	1,629,181	No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
Common Stock	Acquisiton	2014-12-23	8,880	$14.33	1,319,181	No	4	P	Indirect	Through Deerfield Partners, L.P.
Common Stock	Acquisiton	2014-12-23	11,120	$14.33	1,640,301	No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
Common Stock	Acquisiton	2014-12-23	11,100	$14.30	1,330,281	No	4	P	Indirect	Through Deerfield Partners, L.P.
Common Stock	Acquisiton	2014-12-23	13,900	$14.30	1,654,201	No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
Common Stock	Acquisiton	2014-12-23	16,434	$14.48	1,346,715	No	4	P	Indirect	Through Deerfield Partners, L.P.
Common Stock	Acquisiton	2014-12-23	20,580	$14.48	1,674,781	No	4	P	Indirect	Through Deerfield International Master Fund, L.P.

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	P	Indirect	Through Deerfield Partners, L.P.
No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
No	4	P	Indirect	Through Deerfield Partners, L.P.
No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
No	4	P	Indirect	Through Deerfield Partners, L.P.
No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
No	4	P	Indirect	Through Deerfield Partners, L.P.
No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
No	4	P	Indirect	Through Deerfield Partners, L.P.
No	4	P	Indirect	Through Deerfield International Master Fund, L.P.
No	4	P	Indirect	Through Deerfield Partners, L.P.
No	4	P	Indirect	Through Deerfield International Master Fund, L.P.

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	610,588	Indirect	Through Deerfield Special Situations Fund, L.P.
Common Stock	507,703	Indirect	Through Deerfield Special Situations International Master Fund, L.P.

Footnotes

This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P., Deerfield Special Situations International Master Fund, L.P., Deerfield Partners, L.P. and Deerfield International Master Fund, L.P. (collectively, the "Funds"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.
In accordance with Instruction 5 (b)(iv) to Form 3, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.