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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1537529	P Brett Monia	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Svp, Antisense Drug Discovery	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2014-08-26	2,344	$11.27	4,157	No	4	M	Direct
Common Stock	Disposition	2014-08-26	2,344	$38.14	1,813	No	4	S	Direct
Common Stock	Acquisiton	2014-08-26	15,000	$10.29	16,813	No	4	M	Direct
Common Stock	Disposition	2014-08-26	15,000	$38.14	1,813	No	4	S	Direct
Common Stock	Acquisiton	2014-08-26	10,000	$7.25	11,813	No	4	M	Direct
Common Stock	Disposition	2014-08-26	10,000	$38.14	1,813	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Disposition	2014-08-26	2,344	$0.00	2,344	$11.27
Common Stock	Employee Stock Option (right to buy)	Disposition	2014-08-26	15,000	$0.00	15,000	$10.29
Common Stock	Employee Stock Option (right to buy)	Disposition	2014-08-26	10,000	$0.00	10,000	$7.25

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0	2014-01-04	2017-01-03	No	4	M	Direct
5,245	2012-01-03	2018-01-02	No	4	M	Direct
2,266	2013-01-03	2019-01-02	No	4	M	Direct

Footnotes

Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 7/1/14.
Grant of 1/3/11 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vest and became exercisable on 1/3/12. Thereafter, the remaining shares subject to the option vest and became exercisable in 36 equal monthly installments, at the rate of 5,650 shares per year. The option shall be fully vested and exercisable on 1/3/15. The option, before the reported exercises, was exercisable as to 20,245 shares on 8/26/14.
Grant of 1/3/12 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vest and became exercisable on 1/3/13. Thereafter, the remaining shares subject to the option vest and became exercisable in 36 equal monthly installments, at the rate of 4,749 shares per year. The option shall be fully vested and exercisable on 1/3/16. The option, before the reported exercises, was exercisable as to 12,266 shares on 8/26/14.