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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1571498	Epizyme Inc.	EPZM	Pharmaceutical Preparations (2834)	261349956

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1577021	A Robert Copeland	C/O Epizyme, Inc. 400 Technology Square Cambridge MA 02139	Evp And Cso	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock, Par Value $0.0001 Per Share	Acquisiton	2014-06-23	6,550	$0.51	11,855	No	4	M	Direct
Common Stock, Par Value $0.0001 Per Share	Acquisiton	2014-06-23	13,450	$0.60	25,305	No	4	M	Direct
Common Stock, Par Value $0.0001 Per Share	Disposition	2014-06-23	14,816	$28.26	10,489	No	4	S	Direct
Common Stock, Par Value $0.0001 Per Share	Disposition	2014-06-23	5,184	$28.88	5,305	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	M	Direct
No	4	S	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option (Right to Buy)	Disposition	2014-06-23	6,550	$0.00	6,550	$0.51
Common Stock	Stock Option (Right to Buy)	Disposition	2014-06-23	13,450	$0.00	13,450	$0.60

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
1,250		2020-03-17	No	4	M	Direct
96,314		2021-03-10	No	4	M	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock, Par Value $0.0001 Per Share	5,525	Indirect	By Wife

Footnotes

The exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.
The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $27.65 per share to $28.59 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $28.70 per share to $29.115 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
This option was granted on March 18, 2010 with respect to 60,000 shares of Common Stock, with 25% vesting on March 18, 2011 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter.
This option was granted on March 11, 2011 with respect to 109,764 shares of Common Stock, with 25% vesting on March 11, 2012 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter.