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Filing Details

Accession Number:: 0000947871-10-001115
Form Type:: 4
Zero Holdings:: No
Publication Time:: 2010-12-13 18:45:03
Reporting Period:: 2010-12-09

Filing Date:: 2010-12-13
Accepted Time:: 2010-12-13 18:45:03
SEC Url:: Form 4 Filing

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1333170	Nxstage Medical Inc.	NXTM	Electromedical & Electrotherapeutic Apparatus (3845)	043454702

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1055949	D Samuel Isaly	767 3Rd Avenue 30Th Floor New York NY 10017		Yes	No	No	No
1055951	Orbimed Advisors Llc	767 3Rd Avenue 30Th Floor New York NY 10017		Yes	No	No	No

Reported Non-Derivative Transactions

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Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Disposition	2010-12-09	2,356	$22.60	0	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	S	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	2,690,476	Indirect	See Footnotes

Footnotes

As of December 9, 2010, the Reporting Persons hold indirectly 2,690,476 shares of Common Stock on behalf of other persons who have the right to receive or the power to direct the receipt of dividends or proceeds from the sale of such securities. Of this amount, OrbiMed Private Investments III, LP ("OPI III"), formerly known as Caduceus Private Investments III, LP, and OrbiMed Associates III, LP ("Associates"), hold 2,665,000 and 25,476 shares, respectively. OrbiMed Capital GP III LLC ("Capital"), pursuant to its authority as the general partner of OPI III, may be considered to hold indirectly 2,665,000 shares of Common Stock and OrbiMed Advisors LLC ("Advisors"), pursuant to its authority as the managing member of Capital and general partner of Associates, may be considered to hold indirectly 2,690,476 shares of Common Stock.
Advisors is a registered adviser under the Investment Advisers Act of 1940, as amended, and acts as the general partner, or the managing member of the general partner, of certain collective investment funds that hold shares of the Issuer. Samuel D. Isaly, a natural person, owns a controlling interest in Advisors. Capital is the general partner of OPI III and Advisors is the general partner of Associates and managing member of Capital. Pursuant to those relationships, Advisors and Capital have discretionary investment management authority with respect to the assets of OPI III and Associates. Such authority includes the power to vote and otherwise dispose of securities purchased by OPI III and Associates. The Reporting Persons may be deemed to be a director of the Issuer by virtue of having nominated a representative, currently Jonathan T. Silverstein, to serve on the Issuer's board of directors.
The Reporting Persons disclaim beneficial ownership except to the extent of their pecuniary interest. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.