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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1564926	R. Patrick O'neil	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Svp, Legal & General Counsel	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2014-03-03	370	$11.27	3,720	No	4	M	Direct
Common Stock	Disposition	2014-03-03	370	$49.20	3,350	No	4	S	Direct
Common Stock	Acquisiton	2014-03-03	330	$10.82	3,680	No	4	M	Direct
Common Stock	Disposition	2014-03-03	330	$49.20	3,350	No	4	S	Direct
Common Stock	Acquisiton	2014-03-03	800	$10.82	4,150	No	4	M	Direct
Common Stock	Disposition	2014-03-03	800	$50.70	3,350	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Disposition	2014-03-03	370	$0.00	370	$11.27
Common Stock	Employee Stock Option (right to buy)	Disposition	2014-03-03	1,130	$0.00	1,130	$10.82

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0	2011-01-04	2017-01-03	No	4	M	Direct
14,570	2014-01-02	2020-01-01	No	4	M	Direct

Footnotes

Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 1/2/14.
Grant of 1/4/10 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/4/11. Thereafter, the remaining shares subject to the option vest and become exercisalbe in 36 equal monthly installments, at the rate of 4,350 shares per year. Following this transaction, the option was exercisable as to 0 on 3/3/14.
Grant of 1/2/13 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/2/14. Thereafter, the remaining shares subject to the option vest and become exercisalbe in 36 equal monthly installments, at the rate of 3,925 shares per year. Following this transaction, the option was exercisable as to 3,449 on 3/3/14.