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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1073384	H Joseph Wender	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010		Yes	No	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2014-02-03	4,700	$5.72	35,835	No	4	M	Direct
Common Stock	Disposition	2014-02-03	4,700	$48.78	31,135	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Director Stock Option (right to buy)	Disposition	2014-02-03	4,700	$0.00	4,700	$5.72

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
5,300	2008-07-01	2014-06-14	No	4	M	Direct

Footnotes

The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $48.755 to $48.82, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.
Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/14.
Grant of 7/1/2004 to reporting person of stock options under the Isis Pharmacueticals, Inc. 2002 Non Employee Directors' Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 7/1/2005. Thereafter, the remaining shares subject to the option vest and become exercisalbe in 36 equal monthly installments, at the rate of 2,500 shares per year. Following this transaction, the option was exercisable as to 5,300 on 3/4/13.