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Filing Details

Accession Number:: 0000874015-14-000021
Form Type:: 4
Zero Holdings:: No
Publication Time:: 2014-01-17 19:40:26
Reporting Period:: 2014-01-15

Filing Date:: 2014-01-17
Accepted Time:: 2014-01-17 19:40:26
SEC Url:: Form 4 Filing

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1074773	L Elizabeth Hougen	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Svp, Finance & Cfo	No	Yes	No	No

Reported Non-Derivative Transactions

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Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2014-01-15	654	$0.00	954	No	4	M	Direct
Common Stock	Disposition	2014-01-16	250	$47.08	704	No	4	S	Direct
Common Stock	Acquisiton	2014-01-15	542	$0.00	1,246	No	4	M	Direct
Common Stock	Disposition	2014-01-16	207	$47.08	1,039	No	4	S	Direct
Common Stock	Acquisiton	2014-01-15	313	$0.00	1,352	No	4	M	Direct
Common Stock	Disposition	2014-01-16	120	$47.08	1,232	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

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Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Restricted Stock Units	Acquisiton	2014-01-15	7,500	$0.00	7,500	$0.00
Common Stock	Restricted Stock Units	Disposition	2014-01-15	654	$0.00	654	$0.00
Common Stock	Restricted Stock Units	Disposition	2014-01-15	542	$0.00	542	$0.00
Common Stock	Restricted Stock Units	Disposition	2014-01-15	313	$0.00	313	$0.00

Remaning Holdings	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
7,500	No	4	A	Direct
1,961	No	4	M	Direct
1,082	No	4	M	Direct
937	No	4	M	Direct

Footnotes

Acquired pursuant to vesting and release of shares pursuant to an RSU award granted on January 15, 2013.
The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2013.
Acquired pursuant to vesting and release of shares pursuant to an RSU award granted on January 15, 2012.
The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice, dated January 15, 2012.
Each Restricted Stock Unit represents a contingent right to receive one share of Isis common stock, or its equivalent cash value.
Grant 1/15/2014 to reporting person of Restricted Stock Units under the Isis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on January 15, 2015. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2018. The RSU is vested as to 0 shares on January 15, 2014.
Restricted Stock Unit Award granted on January 15, 2013. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2014. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2017.
Restricted Stock Unit Award granted on January 15, 2012. Restricted Stock Units vest in equal annual installments, the first installment vested on January 15, 2013. Upon vesting, the restricted stock units will be paid out in whole shares of Isis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2016.