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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1256126	Peter Mueller	C/O Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge MA 02139	Evp, Global R&D, Cso	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2010-07-15	1,600	$10.41	120,834	No	4	M	Direct
Common Stock	Disposition	2010-07-15	1,600	$34.24	119,234	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option	Disposition	2010-07-15	1,600	$0.00	1,600	$10.41
Common Stock	Stock Option	Acquisiton	2010-07-14	36,250	$0.00	36,250	$33.82

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
23,200		2015-02-02	No	4	M	Direct
36,250	2010-10-14	2020-07-13	No	4	A	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	4,150	Indirect	401(k)

Footnotes

Transaction made pursuant to Dr. Mueller's company approved trading plan under Rule 10b5-1.
Open market sales reported on this line occurred at a weighted average price of $34.24 (range $34.04 to $34.50).
Dr. Mueller undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Fully vested.
Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 07/14/2010.