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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1197034	W Roger Brimblecombe	C/O Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge MA 02139		Yes	No	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2010-03-15	10,000	$38.44	10,000	No	4	M	Direct
Common Stock	Disposition	2010-03-15	10,000	$43.10	0	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option	Disposition	2010-03-15	10,000	$0.00	10,000	$38.44

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0	2000-06-01	2010-05-31	No	4	M	Direct

Footnotes

Transaction made pursuant to Dr. Brimblecombe's company approved sales plan established under Rule 10b5-1.
Open market sales reported on this line occurred at a weighted average price of $43.10 (range $42.80 to $43.52).
Dr. Brimblecombe undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Right to buy under under 1996 Stock and Option Plan, fully vested on grant date, 6/1/2000.