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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1124105	Targacept Inc	TRGT	Pharmaceutical Preparations (2834)	000000000

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1178031	Ralph Snyderman	C/O Targacept, Inc. 200 East First Street, Suite 300 Winston-Salem NC 27101		Yes	No	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2010-02-16	7,500	$9.27	7,500	No	4	M	Direct
Common Stock	Acquisiton	2010-02-16	7,500	$7.10	15,000	No	4	M	Direct
Common Stock	Disposition	2010-02-16	15,000	$19.92	0	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option (Right to Buy)	Disposition	2010-02-16	7,500	$0.00	7,500	$9.27
Common Stock	Stock Option (Right to Buy)	Disposition	2010-02-16	7,500	$0.00	7,500	$7.10

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
17,500		2017-06-19	No	4	M	Direct
0	2009-06-09	2018-07-01	No	4	M	Direct

Footnotes

This stock option vested (vests) and became (becomes) exercisable with respect to (a) one-third of the shares subject to the option on June 20, 2008 and (b) the remaining two-thirds of the shares subject to the option in pro rata quarterly installments over the second and third years following the date of grant so that the option will be vested and exercisable in full on the earlier of (i) June 20, 2010 or (ii) the business day immediately preceding the date of the issuer's annual meeting of stockholders that occurs in 2010, provided that the reporting person remains in service during such periods.