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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1537529	P Brett Monia	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Svp, Antisense Drug Discovery	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2013-09-19	20,000	$15.38	20,769	No	4	M	Direct
Common Stock	Disposition	2013-09-19	20,000	$33.96	769	No	4	S	Direct
Common Stock	Acquisiton	2013-09-19	625	$15.75	1,394	No	4	M	Direct
Common Stock	Disposition	2013-09-19	625	$33.35	769	No	4	S	Direct
Common Stock	Acquisiton	2013-09-19	5,000	$14.65	5,769	No	4	M	Direct
Common Stock	Disposition	2013-09-19	5,000	$33.35	769	No	4	S	Direct
Common Stock	Acquisiton	2013-09-19	22,500	$14.47	23,269	No	4	M	Direct
Common Stock	Disposition	2013-09-19	22,500	$33.35	769	No	4	S	Direct
Common Stock	Acquisiton	2013-09-19	1,875	$11.27	2,644	No	4	M	Direct
Common Stock	Disposition	2013-09-19	1,875	$33.35	769	No	4	S	Direct
Common Stock	Acquisiton	2013-09-20	18,281	$11.27	19,050	No	4	M	Direct
Common Stock	Disposition	2013-09-20	18,281	$35.89	769	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-09-19	20,000	$0.00	20,000	$15.38
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-09-19	625	$0.00	625	$15.75
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-09-19	5,000	$0.00	5,000	$14.65
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-09-19	22,500	$0.00	22,500	$14.47
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-09-19	1,875	$0.00	1,875	$11.27
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-09-20	18,281	$0.00	18,281	$11.27

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0	2012-01-02	2015-01-01	No	4	M	Direct
0	2012-01-01	2014-12-31	No	4	M	Direct
0	2013-02-16	2016-02-15	No	4	M	Direct
0	2013-01-02	2016-01-01	No	4	M	Direct
20,625	2014-01-04	2017-01-03	No	4	M	Direct
2,344	2014-01-04	2017-01-03	No	4	M	Direct

Footnotes

Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 8/12/2013.
Acquired as a result of exercising a stock option that was scheduled to expire on 12/31/14. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 8/12/2013.