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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1442730	S Richard Geary	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Svp, Development	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2013-07-05	1,625	$29.25	3,446	No	4	S	Direct
Common Stock	Acquisiton	2013-07-05	16,960	$14.47	20,406	No	4	M	Direct
Common Stock	Disposition	2013-07-05	16,960	$30.02	3,446	No	4	S	Direct
Common Stock	Acquisiton	2013-07-05	2,220	$11.27	5,666	No	4	M	Direct
Common Stock	Disposition	2013-07-05	2,220	$30.02	3,446	No	4	S	Direct
Common Stock	Acquisiton	2013-07-05	5,000	$19.08	8,446	No	4	M	Direct
Common Stock	Disposition	2013-07-05	5,000	$30.02	3,446	No	4	S	Direct
Common Stock	Acquisiton	2013-07-08	5,007	$11.27	8,453	No	4	M	Direct
Common Stock	Disposition	2013-07-08	5,007	$30.03	3,446	No	4	S	Direct
Common Stock	Acquisiton	2013-07-08	17,933	$11.27	21,379	No	4	M	Direct
Common Stock	Disposition	2013-07-08	17,933	$30.09	3,446	No	4	S	Direct
Common Stock	Acquisiton	2013-07-08	7,060	$10.29	10,506	No	4	M	Direct
Common Stock	Disposition	2013-07-08	7,060	$30.09	3,446	No	4	S	Direct
Common Stock	Acquisiton	2013-07-09	10,358	$10.29	13,804	No	4	M	Direct
Common Stock	Disposition	2013-07-09	10,358	$30.04	3,446	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-07-05	16,960	$0.00	16,960	$14.47
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-07-05	2,220	$0.00	2,220	$11.27
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-07-05	5,000	$0.00	5,000	$19.08
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-07-08	22,940	$0.00	22,940	$11.27
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-07-08	7,060	$0.00	7,060	$10.29
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-07-09	10,358	$0.00	10,358	$10.29

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0	2013-01-02	2016-01-01	No	4	M	Direct
30,420	2014-01-04	2017-01-03	No	4	M	Direct
0	2012-08-16	2015-08-15	No	4	M	Direct
7,480	2014-01-04	2017-01-03	No	4	M	Direct
26,384	2015-01-03	2018-01-02	No	4	M	Direct
16,026	2013-01-03	2018-01-02	No	4	M	Direct

Footnotes

The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 2/12/13.
Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 2/12/13.
Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 10/14/10.