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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
897667	T Stanley Crooke	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Chairman, Ceo And President	Yes	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2013-04-19	30,000	$7.26	31,661	No	4	M	Direct
Common Stock	Disposition	2013-04-19	30,000	$20.01	1,661	No	4	S	Direct
Common Stock	Acquisiton	2013-04-22	20,000	$7.26	21,661	No	4	M	Direct
Common Stock	Disposition	2013-04-22	20,000	$20.99	1,661	No	4	S	Direct
Common Stock	Disposition	2013-04-22	10,000	$20.99	865,391	No	4	S	Indirect	By Family Trust
Common Stock	Disposition	2013-04-23	30,000	$22.10	835,391	No	4	S	Indirect	By Family Trust

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	S	Indirect	By Family Trust
No	4	S	Indirect	By Family Trust

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-04-19	30,000	$0.00	30,000	$7.26
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-04-22	20,000	$0.00	20,000	$7.26

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
20,000	2010-09-21	2013-09-20	No	4	M	Direct
0	2010-09-21	2013-09-20	No	4	M	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	174	Indirect	By wife

Footnotes

Acquired as a result of exercising a stock option that was scheduled to expire on 9/20/2013. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 6/27/2012.
The sale was a result of shares owned. The sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 6/27/2012.
The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.005 to $22.16, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.