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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1206369	Iii Joseph Klein	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010		Yes	No	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2013-03-13	268	$5.93	368	No	4	M	Indirect	By Son
Common Stock	Disposition	2013-03-13	268	$18.01	100	No	4	S	Indirect	By Son
Common Stock	Acquisiton	2013-03-13	6,666	$5.17	6,766	No	4	M	Indirect	By Son
Common Stock	Disposition	2013-03-13	6,666	$18.01	100	No	4	S	Indirect	By Son
Common Stock	Acquisiton	2013-03-13	266	$5.93	266	No	4	M	Indirect	By Daughter
Common Stock	Disposition	2013-03-13	266	$18.01	0	No	4	S	Indirect	By Daughter
Common Stock	Acquisiton	2013-03-13	6,667	$5.17	6,667	No	4	M	Indirect	By Daughter
Common Stock	Disposition	2013-03-13	6,667	$18.01	0	No	4	S	Indirect	By Daughter
Common Stock	Acquisiton	2013-03-13	266	$5.93	266	No	4	M	Indirect	By Son
Common Stock	Disposition	2013-03-13	266	$18.01	0	No	4	S	Indirect	By Son
Common Stock	Acquisiton	2013-03-13	6,667	$5.17	6,667	No	4	M	Indirect	By Son
Common Stock	Disposition	2013-03-13	6,667	$18.01	0	No	4	S	Indirect	By Son

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Indirect	By Son
No	4	S	Indirect	By Son
No	4	M	Indirect	By Son
No	4	S	Indirect	By Son
No	4	M	Indirect	By Daughter
No	4	S	Indirect	By Daughter
No	4	M	Indirect	By Daughter
No	4	S	Indirect	By Daughter
No	4	M	Indirect	By Son
No	4	S	Indirect	By Son
No	4	M	Indirect	By Son
No	4	S	Indirect	By Son

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Director Stock Option (right to buy)	Disposition	2013-03-13	268	$0.00	268	$5.93
Common Stock	Director Stock Option (right to buy)	Disposition	2013-03-13	6,666	$0.00	6,666	$5.17
Common Stock	Director Stock Option (right to buy)	Disposition	2013-03-13	266	$0.00	266	$5.93
Common Stock	Director Stock Option (right to buy)	Disposition	2013-03-13	6,667	$0.00	6,667	$5.17
Common Stock	Director Stock Option (right to buy)	Disposition	2013-03-13	266	$0.00	266	$5.93
Common Stock	Director Stock Option (right to buy)	Disposition	2013-03-13	6,667	$0.00	6,667	$5.17

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
3,899	2010-07-03	2016-07-02	No	4	M	Indirect
0	2009-12-13	2015-12-12	No	4	M	Indirect
3,900	2010-07-03	2016-07-02	No	4	M	Indirect
0	2009-12-13	2015-12-12	No	4	M	Indirect
3,901	2010-07-03	2016-07-02	No	4	M	Indirect
0	2009-12-13	2015-12-12	No	4	M	Indirect

Footnotes

Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 11/15/2012.
The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.00 to $18.03, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.