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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1113481	Medicines Co	MDCO	Pharmaceutical Preparations (2834)	043324394

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1427141	Bernard William O'connor	8 Sylvan Way Parsippany NJ 07054	Sr Vp & Chief Acct. Officer	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Disposition	2013-02-20	570	$32.42	20,220	No	4	S	Direct
Common Stock	Acquisiton	2013-02-21	1,823	$7.31	22,043	No	4	M	Direct
Common Stock	Disposition	2013-02-21	1,823	$32.90	20,220	No	4	S	Direct
Common Stock	Acquisiton	2013-02-21	3,473	$17.45	23,693	No	4	M	Direct
Common Stock	Disposition	2013-02-21	3,473	$32.90	20,220	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Option (right to buy)	Disposition	2013-02-21	1,823	$0.00	1,823	$7.31
Common Stock	Option (right to buy)	Disposition	2013-02-21	3,473	$0.00	3,473	$17.45

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
4,375		2020-02-19	No	4	M	Direct
16,666		2021-02-18	No	4	M	Direct

Footnotes

Represents the number of shares sold to cover the tax expense associated with the vesting of restricted shares held by Mr. O'Connor pursuant to his Restricted Stock Agreements with the Company.
The range of prices for the transactions reported on this line is between $32.40 and $32.43 per share. The price reported above reflects the weighted average sales price. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.
The common stock sales reported on this line of the Form 4 were effected pursuant to a Rule 10b5-1 program adopted by Mr. O'Connor on March 10, 2011 as amended on March 16, 2012.
As of 2/21/2013, the original grant (17,500 shares granted on 2/19/2010) was vested with respect to 13,125 of the shares covered thereby and the remaining 4,375 shares covered by this option vest in equal monthly installments ending on 2/19/2014.
As of 2/21/2013, the original grant (33,333 shares granted on 2/18/2011) was vested with respect to 16,667 of the shares covered thereby and the remaining 16,666 shares covered by this option vest in equal monthly installments ending on 2/18/2015.