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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1564926	R. Patrick O'neil	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Svp, Legal & General Counsel	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2013-02-13	900	$8.00	2,363	No	4	M	Direct
Common Stock	Disposition	2013-02-13	900	$14.17	1,463	No	4	S	Direct
Common Stock	Acquisiton	2013-02-13	5,200	$7.25	6,663	No	4	M	Direct
Common Stock	Disposition	2013-02-13	5,200	$14.17	1,463	No	4	S	Direct
Common Stock	Disposition	2013-02-13	139	$14.17	1,324	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-02-13	900	$0.00	900	$8.00
Common Stock	Employee Stock Option (right to buy)	Disposition	2013-02-13	5,200	$0.00	5,200	$7.25

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
5,800	2011-09-01	2017-08-31	No	4	M	Direct
14,300	2013-01-03	2019-01-02	No	4	M	Direct

Footnotes

The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 30, 2013.
Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purhcase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 30, 2013.
Grant of 9/1/2010 to reporting person of stock options under the Isis Pharamceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 9/1/2011. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 2,500 shares per year. The option is exercisable as to 2,741 shares on 2/13/2013.
Grant of 1/3/2012 to reporting person of stock options under the isis Pharamceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2013. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 4,875 shares per year. The option is exercisable as to 5,281 shares on 2/13/2013.