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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1113481	Medicines Co	MDCO	Pharmaceutical Preparations (2834)	043324394

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1427141	Bernard William O'connor	8 Sylvan Way Parsippany NJ 07054	Chief Accounting Officer	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2013-01-16	25,000	$19.98	46,933	No	4	M	Direct
Common Stock	Disposition	2013-01-16	25,000	$30.00	21,933	No	4	S	Direct
Common Stock	Acquisiton	2013-01-16	11,302	$7.31	33,235	No	4	M	Direct
Common Stock	Disposition	2013-01-16	11,302	$30.00	21,933	No	4	S	Direct
Common Stock	Acquisiton	2013-01-16	13,194	$17.45	35,127	No	4	M	Direct
Common Stock	Disposition	2013-01-16	13,194	$30.00	21,933	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Option (right to buy)	Disposition	2013-01-16	25,000	$0.00	25,000	$19.98
Common Stock	Common stock	Disposition	2013-01-16	11,302	$0.00	11,302	$7.31
Common Stock	Option (right to buy)	Disposition	2013-01-16	13,194	$0.00	13,194	$17.45

Remaning Holdings	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
75,000	2016-04-24	No	4	M	Direct
6,198	2020-02-19	No	4	M	Direct
20,139	2021-02-18	No	4	M	Direct

Footnotes

The common stock sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 program adopted by Mr. O'Connor on March 10, 2011 as amended on March 16, 2012.
As of 1/16/2013, the original grant (100,000 shares granted on 4/24/2006) was fully vested. After the exercise of the options reported hereby, as of 1/16/2013, the remaining 75,000 shares covered by this option are vested but not exercised.
As of 1/16/2013, the original grant (17,500 shares granted on 2/19/2010)was vested with respect to 12,396 of the shares covered thereby and the remaining 5,104 shares covered by this option vest in equal monthly installments ending on 2/19/2014. After the exercise of the options reported hereby, as of 1/16/2013, 1,094 of the shares covered by the option were vested but not exercised.
As of 1/16/2013, the original grant (33,333 shares granted on 2/18/2011) was vested with respect to 15,278 of the shares covered thereby and the remaining 18,055 shares covered by this option vest in equal monthly installments ending on 2/18/2015. After the exercise of the options reported hereby, as of 1/16/2013, 2,084 of the shares covered by the option were vested but not exercised.