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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1505512	Regulus Therapeutics Inc.	RGLS	Pharmaceutical Preparations (2834)	264738379

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
897667	T Stanley Crooke	C/O Regulus Therapeutics Inc. 3545 John Hopkins Court, Suite 210 San Diego CA 92121		Yes	No	Yes	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2012-10-10	6,299,500	$0.00	6,299,500	No	4	C	Indirect	See footnote
Common Stock	Acquisiton	2012-10-10	750,000	$4.00	7,049,500	No	4	P	Indirect	See footnote

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	C	Indirect	See footnote
No	4	P	Indirect	See footnote

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Series A Preferred Stock	Disposition	2012-10-10	6,299,500	$0.00	6,299,500	$0.00

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
0			No	4	C	Indirect

Footnotes

Upon the closing of the Issuer's initial public offering, every 2 shares of Series A Preferred Stock automatically converted into 1 share of Common Stock and had no expiration date.
The shares are held by Isis Pharmaceuticals, Inc ("Isis"). The Reporting Person is an executive officer and director of Isis. The Reporting Person may be deemed to beneficially own the shares. The Reporting Person disclaims beneficial ownership of these shares except to the extent of her pecuniary interest therein.
The shares were purchased at the Issuer's initial public offering.