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Filing Details

Accession Number:: 0000874015-12-000059
Form Type:: 4
Zero Holdings:: No
Publication Time:: 2012-09-06 21:49:17
Reporting Period:: 2012-09-04

Filing Date:: 2012-09-06
Accepted Time:: 2012-09-06 21:49:17
SEC Url:: Form 4 Filing

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
874015	Isis Pharmaceuticals Inc	ISIS	Pharmaceutical Preparations (2834)	330336973

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1073385	Lynne B Parshall	C/O Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad CA 92010	Coo, Secretary	Yes	Yes	No	No

Reported Non-Derivative Transactions

Show Other Fields >>

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Acquisiton	2012-09-04	10,000	$5.25	11,985	No	4	M	Direct
Common Stock	Disposition	2012-09-04	10,000	$15.00	1,985	No	4	S	Direct
Common Stock	Acquisiton	2012-09-04	10,000	$5.25	10,000	No	4	M	Indirect	By daughter
Common Stock	Disposition	2012-09-04	10,000	$15.00	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2012-09-04	10,000	$5.25	10,000	No	4	M	Indirect	By daughter
Common Stock	Disposition	2012-09-04	10,000	$15.00	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2012-09-05	2,000	$5.25	3,985	No	4	M	Direct
Common Stock	Disposition	2012-09-05	2,000	$15.00	1,985	No	4	S	Direct
Common Stock	Acquisiton	2012-09-06	2,494	$6.84	4,479	No	4	M	Direct
Common Stock	Disposition	2012-09-06	2,494	$15.04	1,985	No	4	S	Direct
Common Stock	Acquisiton	2012-09-06	2,506	$5.25	4,491	No	4	M	Direct
Common Stock	Disposition	2012-09-06	2,506	$15.04	1,985	No	4	S	Direct
Common Stock	Acquisiton	2012-09-06	5,000	$5.25	6,985	No	4	M	Direct
Common Stock	Disposition	2012-09-06	5,000	$15.00	1,985	No	4	S	Direct
Common Stock	Acquisiton	2012-09-06	5,000	$6.84	5,000	No	4	M	Indirect	By daughter
Common Stock	Disposition	2012-09-06	5,000	$15.04	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2012-09-06	5,000	$5.25	5,000	No	4	M	Indirect	By daughter
Common Stock	Disposition	2012-09-06	5,000	$15.00	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2012-09-06	5,000	$6.84	5,000	No	4	M	Indirect	Bu daughter
Common Stock	Disposition	2012-09-06	5,000	$15.04	0	No	4	S	Indirect	By daughter
Common Stock	Acquisiton	2012-09-06	5,000	$5.25	5,000	No	4	M	Indirect	By daughter
Common Stock	Disposition	2012-09-06	5,000	$15.00	0	No	4	S	Indirect	By daughter

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	M	Direct
No	4	S	Direct
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Direct
No	4	S	Direct
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	Bu daughter
No	4	S	Indirect	By daughter
No	4	M	Indirect	By daughter
No	4	S	Indirect	By daughter

Reported Derivative Transactions

Show Other Fields >>

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Employee Stock Option (right to buy)	Disposition	2012-09-04	10,000	$0.00	10,000	$5.25
Common Stock	Employee Stock Option (right to buy)	Disposition	2012-09-04	10,000	$0.00	10,000	$5.25
Common Stock	Employee Stock Option (right to buy)	Disposition	2012-09-04	10,000	$0.00	10,000	$5.25
Common Stock	Employee Stock Option (right to buy)	Disposition	2012-09-05	2,000	$0.00	2,000	$5.25
Common Stock	Employee Stock Option (right to buy)	Disposition	2012-09-06	7,506	$0.00	7,506	$5.25
Common Stock	Employee Stock Option (right to uy)	Disposition	2012-09-06	2,494	$0.00	2,494	$6.84
Common Stock	Employee Stock Option (right to buy)	Disposition	2012-09-06	5,000	$0.00	5,000	$5.25
Common Stock	Employee Stock Option (right to buy)	Disposition	2012-09-06	5,000	$0.00	5,000	$5.25
Common Stock	Employee Stock Option (right to buy)	Disposition	2012-09-06	5,000	$0.00	5,000	$6.84
Common Stock	Employee Stock Option (right to buy)	Disposition	2012-09-06	5,000	$0.00	5,000	$6.84

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
9,506	2010-01-03	2013-01-02	No	4	M	Direct
5,000	2008-01-03	2013-01-02	No	4	M	Indirect
5,000	2008-01-03	2013-01-02	No	4	M	Indirect
7,506	2010-01-03	2013-01-02	No	4	M	Direct
0	2010-01-03	2013-01-02	No	4	M	Direct
2,506	2007-01-02	2013-01-01	No	4	M	Direct
0	2008-01-03	2013-01-02	No	4	M	Indirect
0	2008-01-03	2013-01-02	No	4	M	Indirect
5,000	2007-01-02	2013-01-01	No	4	M	Indirect
5,000	2007-01-02	2013-01-01	No	4	M	Indirect

Footnotes

Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 1/16/2012.
Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's daughter on 1/16/2012.