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Filing Details

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
875320	Vertex Pharmaceuticals Inc / Ma	VRTX	Pharmaceutical Preparations (2834)	043039129

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1256126	Peter Mueller	C/O Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge MA 02139	Evp, Global R&D, Cso	No	Yes	No	No

Reported Non-Derivative Transactions

Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership
Common Stock	Acquisiton	2010-10-15	1,600	$10.41	120,834	No	4	M	Direct
Common Stock	Disposition	2010-10-15	1,270	$35.55	119,564	No	4	S	Direct
Common Stock	Disposition	2010-10-15	330	$36.02	119,234	No	4	S	Direct

Equity Swap Involved	Form Type	Code	Nature of Ownership
No	4	M	Direct
No	4	S	Direct
No	4	S	Direct

Reported Derivative Transactions

Sec. Name	Sec. Type	Acquisiton - Disposition	Date	Amount	Price	Amount - 2	Price - 2
Common Stock	Stock Option	Disposition	2010-10-15	1,600	$0.00	1,600	$10.41

Remaning Holdings	Exercise Date	Expiration Date	Equity Swap Involved	Transaction Form Type	Transaction Code	Nature of Ownership
18,400		2015-02-02	No	4	M	Direct

Reported Non-Derivative Holdings

Sec. Name	Remaning Holdings	Nature of Ownership	Explanation
Common Stock	4,150	Indirect	401(k)

Footnotes

Transaction made pursuant to Dr. Mueller's company approved trading plan under Rule 10b5-1.
Open market sales reported on this line occurred at a weighted average price of $35.55 (range $34.88 to $35.87).
Open market sales reported on this line occurred at a weighted average price of $36.02 (range ($35.96 to $36.10).
Dr. Mueller undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
Fully vested.