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Filing Details

Accession Number:: 0000947871-10-000934
Form Type:: 4
Zero Holdings:: No
Publication Time:: 2010-09-14 21:45:54
Reporting Period:: 2010-09-10

Filing Date:: 2010-09-14
Accepted Time:: 2010-09-14 21:45:54
SEC Url:: Form 4 Filing

Issuer

Cik	Name	Symbol	Sector (SIC)	IRS No
1333170	Nxstage Medical Inc.	NXTM	Electromedical & Electrotherapeutic Apparatus (3845)	043454702

Insiders

Cik	Name	Reported Address	Insider Title	Director	Officer	Large Shareholder	Other
1055949	D Samuel Isaly	767 3Rd Avenue 30Th Floor New York NY 10017		Yes	No	Yes	No
1055951	Orbimed Advisors Llc	767 3Rd Avenue 30Th Floor New York NY 10017		Yes	No	Yes	No

Reported Non-Derivative Transactions

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Sec. Name	Acquisiton - Disposition	Date	Amount	Price	Remaning Holdings	Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
Common Stock	Disposition	2010-09-10	193,900	$16.52	3,950,000	No	4	S	Indirect	See Footnotes
Common Stock	Disposition	2010-09-13	100,000	$16.70	3,850,000	No	4	S	Indirect	See Footnotes
Common Stock	Disposition	2010-09-14	96,000	$16.49	3,754,000	No	4	S	Indirect	See Footnotes

Equity Swap Involved	Form Type	Code	Nature of Ownership	Explanation
No	4	S	Indirect	See Footnotes
No	4	S	Indirect	See Footnotes
No	4	S	Indirect	See Footnotes

Footnotes

As of September 10, 2010, the Reporting Persons hold 3,950,000 shares of Common Stock, on behalf of other persons who have the right to receive or the power to direct the receipt of dividends or proceeds from the sale of such securities. Of this amount, Caduceus Private Investments III, LP ("Caduceus") and OrbiMed Associates III, LP ("Associates") hold 3,912,800 shares and 37,200 shares, respectively. OrbiMed Advisors LLC ("Advisors"), pursuant to its authority under its investment advisory contract with Associates, may be considered to hold indirectly 37,200 shares of Common Stock and OrbiMed Capital GP III LLC ("Capital"), pursuant to its authority as general partner of Caduceus, may be considered to hold indirectly 3,912,800 shares of Common Stock.
Advisors is a registered adviser under the Investment Advisers Act of 1940, as amended, that acts as an investment adviser to certain collective investment funds which hold shares of the Issuer. Samuel D. Isaly, a natural person, owns controlling interests in Advisors and Capital. Advisors acts as investment adviser to Associates. Capital acts as general partner to Caduceus. Pursuant to certain agreements and relationships, Advisors and Capital have discretionary investment management authority with respect to the assets of Associates and Caduceus. Such authority includes the power to vote and otherwise dispose of securities purchased by Associates and Caduceus. The Reporting Persons may be deemed to be a director of the issuer by virtue of having nominated a representative, now Jonathan T. Silverstein, to serve on the Issuer's board of directors.
The Reporting Persons disclaim beneficial ownership except to the extent of their pecuniary interest. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.
As of September 13, 2010, the Reporting Persons hold 3,850,000 shares of Common Stock, on behalf of other persons who have the right to receive or the power to direct the receipt of dividends or proceeds from the sale of such securities. Of this amount, Caduceus and Associates hold 3,813,700 shares and 36,300 shares, respectively. Advisors, pursuant to its authority under its investment advisory contract with Associates, may be considered to hold indirectly 36,300 shares of Common Stock and Capital, pursuant to its authority as general partner of Caduceus, may be considered to hold indirectly 3,813,700 shares of Common Stock.
As of September 14, 2010, the Reporting Persons hold 3,754,000 shares of Common Stock, on behalf of other persons who have the right to receive or the power to direct the receipt of dividends or proceeds from the sale of such securities. Of this amount, Caduceus and Associates hold 3,718,600 shares and 35,400 shares, respectively. Advisors, pursuant to its authority under its investment advisory contract with Associates, may be considered to hold indirectly 35,400 shares of Common Stock and Capital, pursuant to its authority as general partner of Caduceus, may be considered to hold indirectly 3,718,600 shares of Common Stock.