Filing Details

An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F);

A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G);

(h)

A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;

A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act;

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

Deerfield Mgmt, L.P. – 1,214,423 shares

Deerfield Mgmt III, L.P. – 889,230 shares

Deerfield Management Company, L.P. – 2,103,653 shares

Deerfield Special Situations Fund, L.P. – 514,423 shares

Deerfield Partners, L.P. – 308,000 shares

Deerfield International Master Fund, L.P. – 392,000 shares

Deerfield Private Design Fund III, L.P. – 889,230 shares

James E. Flynn – 2,103,653 shares

Deerfield Mgmt, L.P. – 4.38%

Deerfield Mgmt III, L.P. – 3.21%

Deerfield Management Company, L.P. – 7.59%

Deerfield Special Situations Fund, L.P. – 1.86%

Deerfield Partners, L.P. – 1.11%

Deerfield International Master Fund, L.P. – 1.41%

Deerfield Private Design Fund III, L.P. – 3.21%

James E. Flynn – 7.59%

Deerfield Mgmt, L.P. - 1,214,423

Deerfield Mgmt III, L.P. – 889,230

Deerfield Management Company, L.P. - 2,103,653

Deerfield Special Situations Fund, L.P. - 514,423

Deerfield Partners, L.P. – 308,000

Deerfield International Master Fund, L.P. – 392,000

Deerfield Private Design Fund III, L.P. – 889,230

James E. Flynn – 2,103,653

Sole power to dispose or to direct the disposition of

Shared power to dispose or to direct the disposition of

Deerfield Mgmt, L.P. - 1,214,423

Deerfield Mgmt III, L.P. – 889,230

Deerfield Management Company, L.P. - 2,103,653

Deerfield Special Situations Fund, L.P. - 514,423

Deerfield Partners, L.P. – 308,000

Deerfield International Master Fund, L.P. – 392,000

Deerfield Private Design Fund III, L.P. – 889,230

James E. Flynn – 2,103,653

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities check the following ☐.

If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than five percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

If a parent holding company or Control person has filed this schedule, pursuant to Rule 13d-1(b)(1)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company or control person has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.

If a group has filed this schedule pursuant to ss.240.13d-1(b)(1)(ii)(J), so indicate under Item 3(j) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to ss.240.13d-1(c) or ss.240.13d-1(d), attach an exhibit stating the identity of each member of the group.

Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5.