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Filing Details

Accession Number:: 0001193125-17-043385
Form Type:: 13G Filing
Publication Date:: 2017-02-14 16:08:34

Filed By:: Dievini Hopp Biotech Holding Gmbh & Co Kg
Company:: Ac Immune Sa (NASDAQ:ACIU)
Filing Date:: 2017-02-14
SEC Url:: 13G Filing

Ownership Summary

Please notice the below summary table is generated without human intervention and may contain errors. Please refer to the complete filing displayed below for exact figures.

Name	Sole Voting Power	Shared Voting Power	Sole Dispositive Power	Shared Dispositive Power	Aggregate Amount Owned Power	Percent of Class
dievini Hopp BioTech holding GmbH Co. KG	0	18,041,000	0	18,041,000	18,041,000	32.0%
DH-Capital GmbH Co. KG	0	18,041,000	0	18,041,000	18,041,000	32.0%
OH Beteiligungen GmbH Co. KG	0	18,041,000	0	18,041,000	18,041,000	32.0%
Dietmar Hopp	0	18,041,000	0	18,041,000	18,041,000	32.0%
Oliver Hopp	0	18,041,000	0	18,041,000	18,041,000	32.0%
Daniel Hopp	0	18,041,000	0	18,041,000	18,041,000	32.0%
Prof. Dr. Friedrich von Bohlen und Halbach	78,750	18,041,000	78,750	18,041,000	18,119,750	32.2%
Prof. Dr. Christof Hettich	174,750	18,041,000	174,750	18,041,000	18,215,750	32.4%
Dr. Mathias Hothum	51,250	18,041,000	51,250	18,041,000	18,092,250	32.1%
filing dievini Hopp BioTech holding GmbH Co. KG ( dievini ) DH-Capital GmbH Co. KG ( DH-Capital ) OH Beteiligungen GmbH Co. KG ( OH Beteiligungen ) Dietmar Hopp Oliver Hopp Daniel Hopp Prof. Dr. Friedrich von Bohlen und Halbach ( Dr. von Bohlen ) Prof. Dr. Christof Hettich ( Dr. Hettich ) Dr. Mathias Hothum ( Dr. Hothum ) Item

Filing

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b),

(c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b)

(Amendment No. )*

AC IMMUNE SA

(Name of Issuer)

Common shares, nominal value CHF 0.02 per share

(Title of Class of Securities)

H00263105

(CUSIP Number)

December 31, 2016

(Date of Event Which Requires Filing of This Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☐ Rule 13d-1(c)

☒ Rule 13d-1(d)

*	The remainder of this cover page shall be filled out for a reporting persons initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be filed for the purpose of Section 18 of the Securities Exchange Act of 1934 (Act) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).


CUSIP NO. H00263105		13 G		Page 2 of 14 Pages


1.	Name of Reporting Persons dievini Hopp BioTech holding GmbH & Co. KG
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☐⁽¹⁾
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0 common shares
		6.	Shared Voting Power 18,041,000 common shares ⁽²⁾
		7.	Sole Dispositive Power 0 common shares
		8.	Shared Dispositive Power 18,041,000 common shares ⁽²⁾
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 18,041,000 common shares ⁽²⁾
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 32.0%⁽³⁾
12.	Type of Reporting Person (See Instructions) OO

(1)

This Schedule 13G is filed by dievini Hopp BioTech holding GmbH & Co. KG (dievini), DH-Capital GmbH & Co. KG (DH-Capital), OH Beteiligungen GmbH & Co. KG (OH Beteiligungen), Dietmar Hopp, Oliver Hopp, Daniel Hopp, Prof. Dr. Friedrich von Bohlen und Halbach (Dr. von Bohlen), Prof. Dr. Christof Hettich (Dr. Hettich), Dr. Mathias Hothum (Dr. Hothum and together with dievini, DH-Capital, OH Beteiligungen, Dietmar Hopp, Oliver Hopp, Daniel Hopp, Dr. von Bohlen and Dr. Hettich, collectively, the Reporting Persons). The Reporting Persons expressly disclaim status as a group for purposes of this Schedule 13G.

(2)	Represents shares held of record by dievini.

(3)

This percentage is calculated based on 56,296,042 shares of the Issuers common shares reported to be issued and outstanding immediately after the consummation of the Issuers initial public offering (including shares issued in connection with the underwriters overallotment option to purchase up to 900,000 additional common shares in connection with the Issuers initial public offering), as reported by the Issuer in its final prospectus for its initial public offering dated as of September 22, 2016 as filed with the Securities and Exchange Commission on September 23, 2016 pursuant to Rule 424(b)(4) under the Securities Act of 1933, as amended.


CUSIP NO. H00263105		13 G		Page 3 of 14 Pages


1.	Name of Reporting Persons DH-Capital GmbH & Co. KG
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☐⁽¹⁾
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0 common shares
		6.	Shared Voting Power 18,041,000 common shares ⁽²⁾
		7.	Sole Dispositive Power 0 common shares
		8.	Shared Dispositive Power 18,041,000 common shares ⁽²⁾
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 18,041,000 common shares ⁽²⁾
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 32.0%⁽³⁾
12.	Type of Reporting Person (See Instructions) OO

(1)

(2)	Represents shares held of record by dievini.

(3)


CUSIP NO. H00263105		13 G		Page 4 of 14 Pages


1.	Name of Reporting Persons OH Beteiligungen GmbH & Co. KG
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☐⁽¹⁾
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0 common shares
		6.	Shared Voting Power 18,041,000 common shares ⁽²⁾
		7.	Sole Dispositive Power 0 common shares
		8.	Shared Dispositive Power 18,041,000 common shares ⁽²⁾
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 18,041,000 common shares ⁽²⁾
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 32.0%⁽³⁾
12.	Type of Reporting Person (See Instructions) OO

(1)

(2)	Represents shares held of record by dievini.

(3)


CUSIP NO. H00263105		13 G		Page 5 of 14 Pages


1.	Name of Reporting Persons Dietmar Hopp
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☐⁽¹⁾
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0 common shares
		6.	Shared Voting Power 18,041,000 common shares ⁽²⁾
		7.	Sole Dispositive Power 0 common shares
		8.	Shared Dispositive Power 18,041,000 common shares ⁽²⁾
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 18,041,000 common shares⁽²⁾
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 32.0%⁽³⁾
12.	Type of Reporting Person (See Instructions) IN

(1)

(2)	Represents shares held of record by dievini.

(3)


CUSIP NO. H00263105		13 G		Page 6 of 14 Pages


1.	Name of Reporting Persons Oliver Hopp
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☐⁽¹⁾
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0 common shares
		6.	Shared Voting Power 18,041,000 common shares ⁽²⁾
		7.	Sole Dispositive Power 0 common shares
		8.	Shared Dispositive Power 18,041,000 common shares ⁽²⁾
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 18,041,000 common shares⁽²⁾
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 32.0%⁽³⁾
12.	Type of Reporting Person (See Instructions) IN

(1)

(2)	Represents shares held of record by dievini.

(3)


CUSIP NO. H00263105		13 G		Page 7 of 14 Pages


1.	Name of Reporting Persons Daniel Hopp
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☐⁽¹⁾
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0 common shares
		6.	Shared Voting Power 18,041,000 common shares ⁽²⁾
		7.	Sole Dispositive Power 0 common shares
		8.	Shared Dispositive Power 18,041,000 common shares ⁽²⁾
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 18,041,000 common shares⁽²⁾
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 32.0%⁽³⁾
12.	Type of Reporting Person (See Instructions) IN

(1)

(2)	Represents shares held of record by dievini.

(3)


CUSIP NO. H00263105		13 G		Page 8 of 14 Pages


1.	Name of Reporting Persons Prof. Dr. Friedrich von Bohlen und Halbach
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☐⁽¹⁾
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 78,750 common shares⁽²⁾
		6.	Shared Voting Power 18,041,000 common shares⁽³⁾
		7.	Sole Dispositive Power 78,750 common shares⁽²⁾
		8.	Shared Dispositive Power 18,041,000 common shares ⁽³⁾
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 18,119,750 common shares⁽⁴⁾
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 32.2%⁽⁵⁾
12.	Type of Reporting Person (See Instructions) IN

(1)

(2)	Represents shares held directly by Dr. von Bohlen through his personal accounts, of which he has sole voting and dispositive power.

(3)	Represents shares held of record by dievini.

(4)	Includes (i) 78,750 common shares held directly by Dr. von Bohlen, of which he has sole voting and dispositive power and (ii) 18,041,000 common shares held of record by dievini, of which Dr. von Bohlen shares voting and dispositive power as a managing director of dievini.

(5)


CUSIP NO. H00263105		13 G		Page 9 of 14 Pages


1.	Name of Reporting Persons Prof. Dr. Christof Hettich
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☐⁽¹⁾
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 174,750 common shares⁽²⁾
		6.	Shared Voting Power 18,041,000 common shares ⁽³⁾
		7.	Sole Dispositive Power 174,750 common shares⁽²⁾
		8.	Shared Dispositive Power 18,041,000 common shares ⁽³⁾
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 18,215,750 common shares ⁽⁴⁾
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 32.4%⁽⁵⁾
12.	Type of Reporting Person (See Instructions) IN

(1)

(2)	Represents shares held directly by Dr. Hettich through his personal accounts, of which he has sole voting and dispositive power.

(3)	Represents shares held of record by dievini.

(4)	Includes (i) 174,750 common shares held directly by Dr. Hettich, of which he has sole voting and dispositive power and (ii) 18,041,000 common shares held of record by dievini, of which Dr. Hettich shares voting and dispositive power as a managing director of dievini.

(5)


CUSIP NO. H00263105		13 G		Page 10 of 14 Pages


1.	Name of Reporting Persons Dr. Mathias Hothum
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☐⁽¹⁾
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 51,250 common shares ⁽²⁾
		6.	Shared Voting Power 18,041,000 common shares ⁽³⁾
		7.	Sole Dispositive Power 51,250 common shares ⁽²⁾
		8.	Shared Dispositive Power 18,041,000 common shares ⁽³⁾
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 18,092,250 common shares ⁽⁴⁾
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 32.1%⁽⁵⁾
12.	Type of Reporting Person (See Instructions) IN

(1)

(2)

Represents (i) 36,500 shares held directly by Dr. Hothum through his personal accounts, of which he has sole voting and dispositive power and (ii) 14,750 common shares issuable upon the exercise of options to purchase common shares that are exercisable within 60 days of December 31, 2016 held by Dr. Hothum.

(3)	Represents shares held of record by dievini.

(4)

Includes (i) 36,500 common shares held directly by Dr. Hothum, of which he has sole voting and dispositive power, (ii) 14,750 common shares issuable upon the exercise of options to purchase common shares that are exercisable within 60 days of December 31, 2016 held by Dr. Hothum and (ii) 18,041,000 common shares held of record by dievini, of which Dr. Hothum shares voting and dispositive power as a managing director of dievini.

(5)

This percentage is calculated based on (i) 56,296,042 shares of the Issuers common shares reported to be issued and outstanding immediately after the consummation of the Issuers initial public offering (including shares issued in connection with the underwriters overallotment option to purchase up to 900,000 additional common shares in connection with the Issuers initial public offering), as reported by the Issuer in its final prospectus for its initial public offering dated as of September 22, 2016 as filed with the Securities and Exchange Commission on September 23, 2016 pursuant to Rule 424(b)(4) under the Securities Act of 1933, as amended and (ii) assumes the 14,750 common shares underlying the options to purchase common shares are deemed outstanding pursuant to Rule 13d-3(d)(1)(i).


CUSIP NO. H00263105		13 G		Page 11 of 14 Pages

Introductory Note: This Schedule 13G is filed by dievini Hopp BioTech holding GmbH & Co. KG (dievini), DH-Capital GmbH & Co. KG (DH-Capital), OH Beteiligungen GmbH & Co. KG (OH Beteiligungen), Dietmar Hopp, Oliver Hopp, Daniel Hopp, Prof. Dr. Friedrich von Bohlen und Halbach (Dr. von Bohlen), Prof. Dr. Christof Hettich (Dr. Hettich), Dr. Mathias Hothum (Dr. Hothum and together with dievini, DH-Capital, OH Beteiligungen, Dietmar Hopp, Oliver Hopp, Daniel Hopp, Dr. von Bohlen and Dr. Hettich, collectively, the Reporting Persons) in respect of common shares of AC Immune SA.

Item 1(a)

Name of Issuer:

AC Immune SA

Item 1(b)

Address of Issuers principal executive offices:

EPFL Innovation Park

Building B

1015 Lausanne

Switzerland

Items 2(a)

Name of Reporting Persons filing:

dievini Hopp BioTech holding GmbH & Co. KG (dievini)

DH-Capital GmbH & Co. KG (DH-Capital)

OH Beteiligungen GmbH & Co. KG (OH Beteiligungen)

Dietmar Hopp

Oliver Hopp

Daniel Hopp

Prof. Dr. Friedrich von Bohlen und Halbach (Dr. von Bohlen)

Prof. Dr. Christof Hettich (Dr. Hettich)

Dr. Mathias Hothum (Dr. Hothum)

Item 2(b)

Address or principal business office or, if none, residence:

The address of the principal business office of dievini, Dietmar Hopp, Dr. von Bohlen, Dr. Hettich and Dr. Hothum is c/o dievini Hopp BioTech holding GmbH & Co. KG, Johann-Jakob-Astor Straße 57, 69190 Walldorf, Germany.

The address of the principal business office of DH-Capital GmbH & Co. KG and OH Beteiligungen GmbH & Co. KG is Heidelberger Straße 43, 69168 Wiesloch, Germany.

The address of the principal business office of Oliver Hopp is Johann-Jakob-Astor-Straße 59, 69190 Walldorf, Germany.

The address of the principal business office of Daniel Hopp is Johann-Jakob-Astor-Straße 57, 69190 Walldorf, Germany.

Item 2(c)

Citizenship:


Name		Citizenship or Place of Organization
dievini		Germany
DH-Capital		Germany
OH Beteiligungen		Germany
Dietmar Hopp		Germany
Oliver Hopp		Germany
Daniel Hopp		Germany
Dr. von Bohlen		Germany
Dr. Hettich		Germany
Dr. Hothum		Germany


CUSIP NO. H00263105		13 G		Page 12 of 14 Pages

Item 2(d)

Title of class of securities:

Common shares, nominal value CHF 0.02 per share

Item 2(e)

CUSIP No.:

H00263105

Item 3

If this statement is filed pursuant to §§ 240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filings is a:

Not applicable.

Item 4

Ownership

The following information with respect to the ownership of common shares of the Issuer by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2016.


Reporting Persons	Common Shares Held Directly			Sole Voting Power		Shared Voting Power		Sole Dispositive Power		Shared Dispositive Power		Beneficial Ownership		Percentage of Class⁽¹⁾
dievini Hopp BioTech holding GmbH & Co. KG⁽²⁾		18,041,000			0		18,041,000		0		18,041,000		18,041,000		32.0	%
DH-Capital GmbH & Co. KG⁽³⁾		0			0		18,041,000		0		18,041,000		18,041,000		32.0	%
OH Beteiligungen GmbH & Co. KG⁽³⁾		0			0		18,041,000		0		18,041,000		18,041,000		32.0	%
Dietmar Hopp⁽³⁾⁽⁴⁾		0			0		18,041,000		0		18,041,000		18,041,000		32.0	%
Oliver Hopp⁽³⁾		0			0		18,041,000		0		18,041,000		18,041,000		32.0	%
Daniel Hopp⁽⁵⁾		0			0		18,041,000		0		18,041,000		18,041,000		32.0	%
Prof. Dr. Friedrich von Bohlen und Halbach⁽³⁾⁽⁴⁾		78,750	⁽⁶⁾		78,750		18,041,000		78,750		18,041,000		18,119,750		32.2	%
Prof. Dr. Christof Hettich⁽³⁾⁽⁴⁾		174,750	⁽⁶⁾		174,750		18,041,000		174,750		18,041,000		18,215,750		32.4	%
Dr. Mathias Hothum⁽⁴⁾		51,250	⁽⁷⁾		51,250		18,041,000		51,250		18,041,000		18,092,250		32.1	%⁽⁸⁾

(1)

(2)

18,041,000 common shares of the Issuer are held of record by dievini.

(3)

DH-Capital, OH Beteiligungen, Dr. von Bohlen and Dr. Hettich are collectively the holders of 100% of the limited partner interest in dievini. DH-Capital and OH Beteiligungen each hold a 40% limited partner interest in dievini and therefore, control the voting and dispositive decisions of dievini together and may be deemed to beneficially own the shares held by dievini. Dietmar Hopp and Oliver Hopp are the ultimate controlling persons of dievini, DH-Capital and OH Beteiligungen, and control the voting and investment decisions of the ultimate parent company of dievini and therefore, may be deemed to beneficially own the shares held by dievini by virtue of their status as controlling persons of dievini.

(4)

The sole general partner of dievini with the authorization to represent is dievini Verwaltungs GmbH; however, 100% of the shares of dievini Verwaltungs GmbH are held by dievini so dievini Verwaltungs GmbH is not considered to have control over dievini. The managing directors of dievini Verwaltungs GmbH are Dietmar Hopp, Dr. von Bohlen, Dr. Hettich and Dr. Hothum. Voting and dispositive decisions made within dievini Verwaltungs GmbH regarding the securities held by dievini are made by at least two managing directors acting together; however, Dietmar Hopp is entitled to represent dievini Verwaltungs GmbH solely. Therefore, in their capacity as managing directors, Dietmar Hopp, Dr. von Bohlen, Dr. Hettich and Dr. Hothum share voting and dispositive power over the shares held by dievini, and may be deemed to beneficially own such shares held by dievini; however, each of Dietmar Hopp, Dr. von Bohlen, Dr. Hettich and Dr. Hothum disclaims beneficial ownership of the shares held by dievini except to the extent of their pecuniary interests therein.

(5)

Daniel Hopp is managing director of the general partner of DH-Capital with the sole power of representation and therefore he is entitled to make voting and dispositive decisions solely. Therefore, by virtue of his position, Daniel Hopp may be deemed to beneficially own such shares held by dievini; however, Daniel Hopp disclaims beneficial ownership of the shares held by dievini except to the extent of his pecuniary interests therein.

(6)

Represents shares held through personal accounts, of which the holder has sole voting and dispositive power.

(7)

(8)

This percentage is calculated based on (i) 56,296,042 shares of the Issuers common shares reported to be issued and outstanding immediately after the consummation of the Issuers initial public offering (including shares issued in connection with the underwriters overallotment option to purchase up to 900,000 additional common shares in connection with the Issuers initial public offering), as reported by the Issuer in its final prospectus for its initial public offering dated as of September 22, 2016 as filed with the Securities and Exchange Commission on September 23, 2016 pursuant to Rule 424(b)(4) under the Securities Act of 1933, as amended and (ii) assumes the 14,750 common shares underlying the options to purchase common shares held by Dr. Hothum are deemed outstanding pursuant to Rule 13d-3(d)(1)(i).


CUSIP NO. H00263105		13 G		Page 13 of 14 Pages

Item 5

Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof, the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: ☐

Item 6

Ownership of More than Five Percent on Behalf of Another Person

Not applicable.

Item 7

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person

Not applicable.

Item 8

Identification and Classification of Members of the Group

Not applicable.

Item 9

Notice of Dissolution of Group

Not applicable.

Item 10

Certifications

Not applicable.


CUSIP NO. H00263105		13 G		Page 14 of 14 Pages

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: February 14, 2017


DIEVINI HOPP BIOTECH HOLDING GMBH & CO. KG

By:		dievini Verwaltungs GmbH
		its General Partner

By:		/s/ Dr. Marc Hauser
		Name: Dr. Marc Hauser
		Title: Attorney-in-fact

DH-CAPITAL GMBH & CO. KG

By:		BW Verwaltungs GmbH
		its General Partner

By:		/s/ Dr. Marc Hauser
		Name: Dr. Marc Hauser
		Title: Attorney-in-fact

OH BETEILIGUNGEN GMBH & CO. KG

By:		OH Verwaltungs GmbH
		its General Partner

By:		/s/ Dr. Marc Hauser
		Name: Dr. Marc Hauser
		Title: Attorney-in-fact

/s/ Dr. Marc Hauser as attorney-in-fact
DIETMAR HOPP

/s/ Dr. Marc Hauser as attorney-in-fact
OLIVER HOPP

/s/ Dr. Marc Hauser as attorney-in-fact
DANIEL HOPP

/s/ Dr. Marc Hauser as attorney-in-fact
FRIEDRICH VON BOHLEN UND HALBACH

/s/ Dr. Marc Hauser as attorney-in-fact
CHRISTOF HETTICH

/s/ Dr. Marc Hauser as attorney-in-fact
MATHIAS HOTHUM

Exhibit(s):

1 Power of Attorney

2 - Joint Filing Statement