Filing Details

The remainder of this cover page shall be filled out for a reporting persons initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

 Name of Reporting Person:

 Novo Holdings A/S

 Check the Appropriate Box if a Member of Group (See Instructions):

 (a) ☐  (b) ☐

 SEC Use Only:

 Source of Funds:

 WC

 Check if Disclosure of Legal Proceedings is Required Pursuant to Items2(d) or 2(e):

 ☐

 Citizenship or Place of Organization:

 Denmark

Number of

Shares Beneficially 

Owned By

Each

Reporting

Person

With:

 Sole Voting Power:

 6,898,584 (1)

 Shared Voting Power:

 0

 Sole Dispositive Power:

 6,898,584 (1)

 Shared Dispositive Power:

 0

 Aggregate Amount Beneficially Owned by Each Reporting Person:

 6,898,584 (1)

 Check if the Aggregate Amount in Row (11) Excludes Certain Shares:

 ☐

 Percent of Class Represented By Amount In Row (11):

 10.1% (2)

 Type of Reporting Person:

 CO

Represents (i) 4,429,449 shares of Common Stock and (ii) currently exercisable warrants to acquire 2,469,135 shares of common stock at an exercise price of $2.47 per share.

Based upon (i) 65,880,914 shares of the Issuers Common Stock outstanding as of February 28, 2024, as reported in the Issuers Form 10-K/A filed with the Securities and Exchange Commission (the SEC) on March 22, 2024 plus (ii) 2,469,135 shares of Common Stock issuable upon the exercise of the warrants held by Novo Holdings A/S.

Identity and Background

Novo Holdings A/S, a Danish corporation, is an investment firm focused on life sciences and finance that is wholly owned by Novo Nordisk Foundation (the Foundation), a Danish commercial foundation. Novo Holdings A/S is the holding company in the group of Novo companies (currently comprised of Novo Nordisk A/S and Novozymes A/S) and is responsible for managing the Foundations assets, including its financial assets. Based on the governance structure of Novo Holdings A/S and the Foundation, the Foundation is not deemed to have any beneficial ownership of the securities of the Issuer held by Novo Holdings A/S.

The business address of both Novo Holdings A/S and the Foundation is Tuborg Havnevej 19, 2900 Hellerup, Denmark.

Novo Holdings A/S, a holding company that is responsible for managing the Foundations assets, provides seed and venture capital to development stage companies and invests in well-established companies within the life science and biotechnology sector.

Within the last five years, neither Novo Holdings A/S, the Foundation, nor any person named in the updated Schedule I has been convicted in any criminal proceedings.

Within the last five years, neither Novo Holdings A/S, the Foundation, nor any person named in the updated Schedule I was a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

Source and Amount of Funds or Other Consideration

Interest in Securities of the Issuer

Novo Holdings A/S beneficially owns 6,898,584 shares of Common Stock (the Novo Shares) representing approximately 10.1% of the Issuers outstanding shares of Common Stock, based upon (i) 65,880,914 shares of the Issuers Common Stock outstanding as of February 28, 2024, as reported in the Issuers Form 10-K/A filed with the SEC on March 22, 2024 plus (ii) 2,469,135 shares of Common Stock issuable upon the exercise of the warrants held by Novo Holdings A/S.

Novo Holdings A/S is a Danish corporation wholly owned by the Novo Nordisk Foundation. Novo Holdings A/S has the sole power to vote and dispose of the Novo Shares. Neither the Foundation nor any person listed on the updated Schedule I has the power to direct the vote as to, or the disposition of the Novo Shares.

Except as described herein, Novo Holdings A/S has not effected any transactions in the Issuers Common Shares within the past 60 days and neither the Foundation nor any person listed on the updated Schedule I has effected any transactions in the Issuers Common Shares within the past 60 days.

Novo Holdings A/S does not know of any other person having the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Novo Shares.

Not applicable.

/s/ Barbara Fiorini Due

Novo Holdings A/S

Name, Title

Address

Principal Occupation

Citizenship

St.-Anna-Str. 17

92318 Neumarkt i.d.OPf

Germany

Ingeborg Vænge 2,

2960 Rungsted Kyst
Denmark

Novo Nordisk Foundation

Name, Title

Address

Principal Occupation

Citizenship

Lars Rebien Sørensen,

Chair of the Board

Lars Henrik Munch

Vice Chair of the Board

Galionsvej 46

1437 København K

Denmark

Steen Riisgaard,

Board Director

Lars Henrik Fugger

Board Director

72 Staunton Road, Headington

OX3 7TP
Great Britain

Liselotte Højgaard

Board Director

Grønningen 21, 4.

1270 København K

Denmark

Nana Bule Sejbaek

Board Director

Vinrankevej 3

2900 Hellerup

Denmark

Christopher Ashby Voigt

Board Director

Mads Boritz Grøn,

Board Director

Horsevænget 4

3400 Hillerød

Denmark

Ole Jakob Müller

Board Director

Borgmester Jensens Allé 11, 4. 003

2100 Copenhagen Ø Denmark

Stig Strøbaek,

Board Director

Mads Krogsgaard Thomsen

Chief Executive Officer

Præstevejen 38

3230 Græsted

Denmark