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NAMES OF REPORTING PERSONS

Third Rock Ventures III, L.P.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐ (b) ☒

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

Accession Number:: 0001193125-24-036266
Form Type:: 13G Filing
Publication Date:: 2024-02-13 19:00:00

Filed By:: Third Rock Ventures Iii, L.p.
Company:: Fulcrum Therapeutics Inc. (NASDAQ:FULC)
Filing Date:: 2024-02-14
SEC Url:: 13G Filing

Ownership Summary

Please notice the below summary table is generated without human intervention and may contain errors. Please refer to the complete filing displayed below for exact figures.

Name	Sole Voting Power	Shared Voting Power	Sole Dispositive Power	Shared Dispositive Power	Aggregate Amount Owned Power	Percent of Class
Third Rock Ventures III	0	0	0	0	0	0%
Third Rock Ventures GP III	0	0	0	0	0	0%
TRV GP III	0	0	0	0	0	0%
Third Rock Ventures IV	0	2,343,154	0	2,343,154	2,343,154	3.8%
Third Rock Ventures GP IV	0	2,343,154	0	2,343,154	2,343,154	3.8%
TRV GP IV	0	2,343,154	0	2,343,154	2,343,154	3.8%
Robert I. Tepper	156,189	0	156,189	0	156,189	0.3%

Filing

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 3)*

Fulcrum Therapeutics, Inc.

(Name of Issuer)

COMMON STOCK, $0.001 PAR VALUE PER SHARE

(Title of Class of Securities)

359616109

(CUSIP Number)

December 31, 2023

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☐ Rule 13d-1(c)

☒ Rule 13d-1(d)

*	The remainder of this cover page shall be filled out for a reporting persons initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be filed for the purpose of Section 18 of the Securities Exchange Act of 1934 (Act) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).


CUSIP No. 359616109		SCHEDULE 13G		Page 2 of 13 Pages

(1)	The percent of class was calculated based on 61,822,554 shares of common stock issued and outstanding as of October 31, 2023 as disclosed in the Issuers 10-Q filed with the Securities and Exchange Commission on November 7,2023.


CUSIP No. 359616109		SCHEDULE 13G		Page 3 of 13 Pages


CUSIP No. 359616109		SCHEDULE 13G		Page 4 of 13 Pages


CUSIP No. 359616109		SCHEDULE 13G		Page 5 of 13 Pages


CUSIP No. 359616109		SCHEDULE 13G		Page 6 of 13 Pages


CUSIP No. 359616109		SCHEDULE 13G		Page 7 of 13 Pages


CUSIP No. 359616109		SCHEDULE 13G		Page 8 of 13 Pages


CUSIP No. 359616109		SCHEDULE 13G		Page 9 of 13 Pages

Item 1.

Issuer

(a)

Name of Issuer:

Fulcrum Therapeutics, Inc. (the Issuer)

(b)

Address of Issuers Principal Executive Offices:

26 Landsdowne Street

Cambridge, MA 02139

Item 2.

Filing Person

(a) (c)

Name of Persons Filing; Address; Citizenship:

(i)

Third Rock Ventures III, L.P. (TRV III);

(ii)

Third Rock Ventures GP III, L.P. (TRV GP III), which is the sole general partner of TRV III;

(iii)

TRV GP III, LLC (TRV GP III LLC), which is the sole general partner of TRV GP III;

(iv)

Third Rock Ventures IV, L.P. (TRV IV);

(v)

Third Rock Ventures GP IV, L.P. (TRV GP IV), which is the sole general partner of TRV IV;

(vi)

TRV GP IV, LLC (TRV GP IV LLC), which is the sole general partner of TRV GP IV; and

(vii)

Robert I. Tepper (Tepper, and collectively with TRV III, TRV GP III, TRV GP III LLC, TRV IV, TRV GP IV and TRV GP IV LLC, the Reporting Persons), the managing member of TRV GP III LLC.

The address of the principal business office of each of the Reporting Persons is Third Rock Ventures, LLC, 201 Brookline Ave, Suite 1401, Boston, MA 02215.

Each of TRV III, TRV GP III, TRV IV and TRV GP IV is a Delaware limited partnership. Each of TRV GP III LLC and TRV GP IV LLC is a Delaware limited liability company. Tepper is a United States citizen.

(d)

Title of Class of Securities:

Common stock, $0.001 par value per share, (the Common Stock)

(e)

CUSIP Number:

359616109

Item 3.

If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:


(a)	☐	Broker or dealer registered under Section 15 of the Act;

(b)	☐	Bank as defined in Section 3(a)(6) of the Act;

(c)	☐	Insurance company as defined in Section 3(a)(19) of the Act;

(d)	☐	Investment company registered under Section 8 of the Investment Company Act of 1940;


CUSIP No. 359616109		SCHEDULE 13G		Page 10 of 13 Pages


(e)	☐	An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

(f)	☐	An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F);

(g)	☐	A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G);

(h)	☐	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)	☐	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940;

(j)	☐	A non-U.S. institution in accordance with Rule 240.13d-1(b)(1)(ii)(J);

(k)	☐	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with Rule 240.13d-1(b)(1)(ii)(J), please specify the type of institution:

	If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution:

Item 4.

Ownership.

(a) and (b) Amount beneficially owned:

(i)

TRV III directly owns 0 shares of Common Stock (the III Shares), which represents 0% of the outstanding shares of Common Stock.

(ii)

TRV GP III is the general partner of TRV III and may be deemed to beneficially own any shares of Common Stock held by TRV III (if any).

(iii)

TRV GP III LLC is the general partner of TRV GP III and may be deemed to beneficially own any shares of Common Stock held by TRV III (if any).

(iv)

TRV IV directly owns 2,343,154 shares of Common Stock (the Shares), which represents approximately 3.8% of the outstanding shares of Common Stock.

(v)

TRV GP IV is the general partner of TRV IV and may be deemed to beneficially own the Shares.

(vi)

TRV GP IV LLC is the general partner of TRV GP IV and may be deemed to beneficially own the Shares.

(vii)

As the managing member of TRV GP III LLC Tepper may be deemed to beneficially own any shares of Common Stock held by TRV III (if any). Additionally, Tepper directly owns 156,189 shares of Common Stock, which represents approximately 0.3% of the outstanding shares of Common Stock.

(c)

Number of shares as to which such person has:


	Number of Shares of Common Stock
Reporting Person	(i)		(ii)		(iii)		(iv)
TRV III		0		0		0		0
TRV GP III		0		0		0		0
TRV GP III LLC		0		0		0		0
TRV IV		0		2,343,154		0		2,343,154
TRV GP IV		0		2,343,154		0		2,343,154
TRV GP IV LLC		0		2,343,154		0		2,343,154
Tepper		156,189		0		156,189		0


CUSIP No. 359616109		SCHEDULE 13G		Page 11 of 13 Pages

(i)

Sole power to vote or direct the vote

(ii)

Shared power to vote or to direct the vote

(iii)

Sole power to dispose or to direct the disposition of

(iv)

Shared power to dispose or to direct the disposition of

The percent of class was calculated based on 61,822,554 shares of common stock issued and outstanding as of October 31, 2023 as disclosed in the Issuers 10-Q filed with the Securities and Exchange Commission on November 7, 2023.

Item 5.

Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ☒.

Item 6.

Ownership of More than Five Percent on Behalf of Another Person.

Not applicable.

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

Not applicable.

Item 8.

Identification and Classification of Members of the Group.

Not applicable.

Item 9.

Notice of Dissolution of Group.

Not applicable.

Item 10.

Certification.

Not applicable.


CUSIP No. 359616109		SCHEDULE 13G		Page 12 of 13 Pages

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: February 14, 2024


THIRD ROCK VENTURES III, L.P.

By: THIRD ROCK VENTURES GP III, L.P.,
General Partner

By: TRV GP III, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

THIRD ROCK VENTURES GP III, L.P.

By: TRV GP III, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

TRV GP III, LLC

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

THIRD ROCK VENTURES IV, L.P.

By: THIRD ROCK VENTURES GP IV, L.P.,
General Partner

By: TRV GP IV, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer


CUSIP No. 359616109		SCHEDULE 13G		Page 13 of 13 Pages



THIRD ROCK VENTURES GP IV, L.P.

By: TRV GP IV, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

TRV GP IV, LLC

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

ROBERT I. TEPPER

/s/ Kevin Gillis, As attorney-in-fact
Robert I. Tepper