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Name of Reporting Person

  I.R.S. Identification No. of Above Person (Entities Only)

  Intersouth Partners VII, L.P.

Check the Appropriate Box if a Member of a Group

(a) ☐ (b) ☐

SEC Use Only

Citizenship or Place of Organization

Delaware

Accession Number:: 0001193125-23-035881
Form Type:: 13G Filing
Publication Date:: 2023-02-12 19:00:00

Filed By:: Intersouth Partners Vii L P
Company:: Lyra Therapeutics Inc. (NASDAQ:LYRA)
Filing Date:: 2023-02-13
SEC Url:: 13G Filing

Ownership Summary

Please notice the below summary table is generated without human intervention and may contain errors. Please refer to the complete filing displayed below for exact figures.

Name	Shared Voting Power	Shared Dispositive Power	Aggregate Amount Owned Power	Percent of Class
Intersouth Partners VII	738,203	738,203	738,203	2.3%
Intersouth Associates VII	738,203	738,203	738,203	2.3%
Dennis Dougherty	738,203	738,203	738,203	2.3%
Mitch Mumma	738,203	738,203	738,203	2.3%

Filing

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. 1)*

Lyra Therapeutics, Inc.

(Name of Issuer)

Common Stock, $0.001 par value per share

(Title of Class of Securities)

55234L105

(CUSIP Number)

December 31, 2022

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

*	The remainder of this cover page shall be filled out for a reporting persons initial filing of this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be filed for the purpose of Section 18 of the Securities Exchange Act of 1934 (Act) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.

This percentage is calculated based upon 31,827,008 shares of common stock outstanding on November 1, 2022 as reported by Lyra Therapeutics, Inc. (the Issuer) on its Form 10-Q for the quarterly period ended September 30, 2022 (the Form 10-Q) as filed with the Securities and Exchange Commission (the SEC) on November 8, 2022.

²	This percentage is calculated based upon 31,827,008 shares of common stock outstanding on November 1, 2022 as reported by the Issuer on its Form 10-Q as filed with the SEC on November 8, 2022.

³	This percentage is calculated based upon 31,827,008 shares of common stock outstanding on November 1, 2022 as reported by the Issuer on its Form 10-Q as filed with the SEC on November 8, 2022.

⁴	This percentage is calculated based upon 31,827,008 shares of common stock outstanding on November 1, 2022 as reported by the Issuer on its Form 10-Q as filed with the SEC on November 8, 2022.


Item 1(a)		Name of Issuer

		Lyra Therapeutics, Inc. (the Issuer)

Item 1(b)		Address of Issuers Principal Executive Offices

		480 Arsenal Way
		Watertown, Massachusetts 02472

Item 2(a)		Name of Persons Filing

		Intersouth Partners VII, L.P. (ISP VII)
		Intersouth Associates VII, LLC (ISA VII, LLC)
		Dennis Dougherty
		Mitch Mumma (together with ISP VII, ISA VII, LLC, and Mr. Dougherty, the Reporting Persons).

Item 2(b)		Address of Principal Business Office, or if none, Residence

		For each of the Reporting Persons:

		c/o Intersouth Partners
		4711 Hope Valley Road
		Suite 4F 632
		Durham, North Carolina 27707

Item 2(c)		Citizenship

		ISP VII Delaware limited partnership
		ISA VII, LLC Delaware limited liability company
		Dennis Dougherty United States of America
		Mitch Mumma United States of America

Item 2(d)		Title of Class of Securities

		Common Stock, $0.001 par value per share

Item 2(e)		CUSIP Number

		55234L105

Item 3.		Filing pursuant to Rules 13d-1(b) or 13d-2(b) or (c)

		Not Applicable


Item 4.		Ownership

(a)		Amount Beneficially Owned

		The Reporting Persons are the owners of an aggregate of 738,203 shares of Common Stock, which represents 2.3% of the Issuers outstanding common stock based upon 31,827,008 shares of common stock outstanding on November 1, 2022 as reported on its Form 10-Q as filed with the SEC on November 8, 2022. ISP VII directly beneficially owns 738,203 shares of Common Stock, or 2.3% of the Issuers common stock outstanding. ISA VII, LLC, as the general partner of ISP VII, may be deemed to indirectly beneficially own the securities owned by ISP VII. Messrs. Dougherty and Mumma, as Member Managers of ISA VII, LLC, may be deemed to indirectly beneficially own the securities owned by ISP VII.

		Each of (i) ISP VII, (ii) ISA VII, LLC, and (iii) Messrs. Dougherty and Mumma, may be deemed to share the power to vote or direct the voting of, and to dispose or direct the disposition of, the securities of Issuer that are directly beneficially owned by ISP VII. Each of Messrs. Dougherty and Mumma disclaims beneficial ownership of all securities other than those he owns by virtue of his indirect pro rata interest as a member of ISA VII, LLC.

(b)		Percent of Class

		ISP VII 2.3%
		ISA VII, LLC 2.3%
		Mitch Mumma 2.3%
		Dennis Dougherty 2.3%

		The above percentages are based on 31,827,008 shares of common stock outstanding on November 1, 2022 as reported on its Form 10-Q as filed with the SEC on November 8, 2022.

(c)		Number of shares as to which the person has;

		(i) sole power to vote or direct the vote:

		ISP VII 0
		ISA VII, LLC 0
		Mitch Mumma 0
		Dennis Dougherty 0

		(ii) shared power to vote or direct the vote:

		ISP VII 738,203
		ISA VII, LLC 738,203
		Mitch Mumma 738,203
		Dennis Dougherty 738,203
		(See Item 4(a))

		(iii) sole power to dispose or direct the disposition of:

		ISP VII 0
		ISA VII, LLC 0
		Mitch Mumma 0
		Dennis Dougherty 0

		(iv) shared power to dispose or direct the disposition of:

		ISP VII 738,203
		ISA VII, LLC 738,203
		Mitch Mumma 738,203
		Dennis Dougherty 738,203
		(See Item 4(a))


Item 5.		Ownership of Five Percent or Less of a Class

		If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following. ☒

Item 6.		Ownership of More than Five Percent on Behalf of Another Person

		Not Applicable

Item 7.		Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company

		Not Applicable.

Item 8.		Identification and Classification of Members of the Group

		Not Applicable.

Item 9.		Notice of Dissolution of Group

		Not Applicable

Item 10.		Certification

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

Exhibit Index

Exhibit A

Joint Filing Agreement by and among the Reporting Persons dated February 12, 2021

(incorporated by reference to Exhibit A of the Schedule 13G filed with the SEC on February 12, 2021).

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement with respect to such person is true, complete and correct.

Date: February 13, 2023


INTERSOUTH PARTNERS VII, L.P.

By:		Intersouth Associates VII, LLC its General Partner

By:		/s/ Dennis Dougherty
Name:		Dennis Dougherty
Title:		Member Manager


INTERSOUTH ASSOCIATES VII, L.P.

By:		Intersouth Associates VII, LLC its General Partner


By:		/s/ Mitch Mumma
Name:		Mitch Mumma
Title:		Member Manager

/s/ Dennis Dougherty
Dennis Dougherty

/s/ Mitch Mumma
Mitch Mumma