Filing Details

The remainder of this cover page shall be filled out for a reporting persons initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

Name of Reporting Person

The Column Group II, LP

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

WC

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

Delaware

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

2,568,674 (1)(2)

Shared Voting Power:

0

Sole Dispositive Power:

2,568,674 (1)(2)

Shared Dispositive Power:

0

Aggregate Amount Beneficially Owned by Each Reporting Person:

2,568,674 (1)(2)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

8.7%(3)

Type of Reporting Person (See Instructions):

PN

The securities are directly held by The Column Group II, LP (TCG II LP). The Column Group II GP, LP (TCG II GP) is the general partner of TCG II LP and may be deemed to have voting and investment power with respect to these securities. The managing partners of TCG II GP are David Goeddel and Peter Svennilson (collectively, the TCG II GP Managing Partners). The TCG II GP Managing Partners may be deemed to share voting and investment power with respect to such shares.

Includes 50,000 shares previously reported as held by The Column Group II Management, LP.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Issuers quarterly report on Form 10-Q for the quarter ended June 30, 2021, filed with the United States Securities and Exchange Commission on August 11, 2021 (the Form 10-Q).

Name of Reporting Person

The Column Group II GP, LP

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

AF

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

Delaware

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

0

Shared Voting Power:

2,568,674 (1)

Sole Dispositive Power:

0

Shared Dispositive Power:

2,568,674 (1)

Aggregate Amount Beneficially Owned by Each Reporting Person:

2,568,674 (1)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

8.7%

Type of Reporting Person (See Instructions):

PN

The securities are directly held by TCG II LP. TCG II GP is the general partner of TCG II LP and may be deemed to have voting and investment power with respect to these securities. The managing partners of TCG II GP are the TCG II GP Managing Partners. The TCG II GP Managing Partners may be deemed to share voting and investment power with respect to such shares.

Includes 50,000 shares previously reported as held by The Column Group II Management, LP.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Form 10-Q.

Name of Reporting Person

Ponoi Capital, LP

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

WC

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

Delaware

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

1,599,417(1)

Shared Voting Power:

0

Sole Dispositive Power:

1,599,417(1)

Shared Dispositive Power:

0

Aggregate Amount Beneficially Owned by Each Reporting Person:

1,599,417(1)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

5.4%(2)

Type of Reporting Person (See Instructions):

PN

The securities are directly held by Ponoi Capital, LP (Ponoi LP). Ponoi Management, LLC (Ponoi LLC) is the general partner of Ponoi LP and may be deemed to have voting and investment power with respect to these securities. The managing partners of Ponoi LLC are the TCG II GP Managing Partners and Tim Kutzkey (collectively, the Ponoi Managing Partners). The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Form 10-Q.

Name of Reporting Person

Ponoi Management, LLC

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

AF

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

Delaware

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

0

Shared Voting Power:

1,599,417(1)

Sole Dispositive Power:

0

Shared Dispositive Power:

1,599,417(1)

Aggregate Amount Beneficially Owned by Each Reporting Person:

1,599,417(1)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

5.4%(2)

Type of Reporting Person (See Instructions):

OO

The shares are directly held by Ponoi LP. Ponoi LLC is the general partner of Ponoi LP and may be deemed to have voting and investment power with respect to these shares. The managing partners of Ponoi LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Form 10-Q.

Name of Reporting Person

Ponoi Capital II, LP

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

WC

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

Delaware

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

145,401(1)

Shared Voting Power:

0

Sole Dispositive Power:

145,401(1)

Shared Dispositive Power:

0

Aggregate Amount Beneficially Owned by Each Reporting Person:

145,401(1)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

0.5%(2)

Type of Reporting Person (See Instructions):

PN

The shares are directly held by Ponoi Capital II, LP (Ponoi II LP). Ponoi II Management, LLC (Ponoi II LLC) is the general partner of Ponoi II LP and may be deemed to have voting and investment power with respect to these shares. The managing partners of Ponoi II LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Form 10-Q.

Name of Reporting Person

Ponoi II Management, LLC

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

AF

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

Delaware

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

0

Shared Voting Power:

145,401(1)

Sole Dispositive Power:

0

Shared Dispositive Power:

145,401(1)

Aggregate Amount Beneficially Owned by Each Reporting Person:

145,401(1)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

0.5%(2)

Type of Reporting Person (See Instructions):

OO

The shares are directly held by Ponoi II LP. Ponoi II LLC is the general partner of Ponoi II LP and may be deemed to have voting and investment power with respect to these shares. The managing partners of Ponoi II LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Form 10-Q.

Name of Reporting Person

The Column Group, LLC

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

AF

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

Delaware

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

0

Shared Voting Power:

91(1)

Sole Dispositive Power:

0

Shared Dispositive Power:

91(1)

Aggregate Amount Beneficially Owned by Each Reporting Person:

91(1)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

0.0%(2)

Type of Reporting Person (See Instructions):

OO

The shares are directly held The Column Group LLC (TCG LLC). The managing members of TCG LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Form 10-Q.

Name of Reporting Person

Peter Svennilson

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

AF

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

Sweden

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

43,664(1)

Shared Voting Power:

4,313,583(2)

Sole Dispositive Power:

43,664(1)

Shared Dispositive Power:

4,313,583(2)

Aggregate Amount Beneficially Owned by Each Reporting Person:

4,357,247(1)(2)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

14.8%

Type of Reporting Person (See Instructions):

IN

Consists of (i) 34,425 shares held directly by Peter Svennilson and (ii) 9,239 shares underlying options to purchase shares of Common Stock held by Peter Svennilson, exercisable within 60 days of this statement.

Consists of (i) 2,568,674 shares held directly by TCG II LP (ii) 1,599,417 shares held directly by Ponoi LP (iii) 145,401 shares held directly by Ponoi II LP and (iv) 91 shares held directly by TCG LLC. TCG II GP is the general partner of TCG II LP and may be deemed to have voting and investment power with respect to the shares held by TCG II LP. The managing partners of TCG II GP are the TCG II GP Managing Partners. The TCG II GP Managing Partners may be deemed to share voting and investment power with respect to the shares held by TCG II LP. Ponoi LLC is the general partner of Ponoi LP and may be deemed to have voting and investment power with respect to the shares held by Ponoi LP. Ponoi II LLC is the general partner of Ponoi II LP and may be deemed to have voting and investment power with respect to the shares held by Ponoi LP. The managing partners of each of Ponoi LLC, Ponoi II LLC and TCG LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to the shares held by each of Ponoi LP, Ponoi II LP and TCG LLC.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Form 10-Q, plus 9,239 shares underlying options to purchase shares of Common Stock held by Peter Svennilson, exercisable within 60 days of this statement.

Name of Reporting Person

David V. Goeddel

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

AF

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

U.S.A.

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

34,425(1)

Shared Voting Power:

4,313,583(2)

Sole Dispositive Power:

34,425(1)

Shared Dispositive Power:

4,313,583(2)

Aggregate Amount Beneficially Owned by Each Reporting Person:

4,348,008(1)(2)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

14.7%(3)

Type of Reporting Person (See Instructions):

IN

These shares are held directly by David V. Goeddel.

Consists of (i) 2,568,674 shares held directly by TCG II LP (ii) 1,599,417 shares held directly by Ponoi LP (iii) 145,401 shares held directly by Ponoi II LP and (iv) 91 shares held directly by TCG LLC. TCG II GP is the general partner of TCG II LP and may be deemed to have voting and investment power with respect to the shares held by TCG II LP. The managing partners of TCG II GP are the TCG II GP Managing Partners. The TCG II GP Managing Partners may be deemed to share voting and investment power with respect to the shares held by TCG II LP. Ponoi LLC is the general partner of Ponoi LP and may be deemed to have voting and investment power with respect to the shares held by Ponoi LP. Ponoi II LLC is the general partner of Ponoi II LP and may be deemed to have voting and investment power with respect to the shares held by Ponoi LP. The managing partners of each of Ponoi LLC, Ponoi II LLC and TCG LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to the shares held by each of Ponoi LP, Ponoi II LP and TCG LLC.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Form 10-Q.

Name of Reporting Person

Tim Kutzkey

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only:

Source of Funds (See Instructions):

AF

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e):

☐

Citizenship or Place of Organization:

U.S.A.

Number of

Shares

Beneficially by

Owned by

Each

Reporting

Person

With

Sole Voting Power:

0

Shared Voting Power:

1,744,909(1)

Sole Dispositive Power:

0

Shared Dispositive Power:

1,744,909(1)

Aggregate Amount Beneficially Owned by Each Reporting Person:

1,744,909(1)

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions):

☐

Percent of Class Represented by Amount in Row (11):

5.9%

Type of Reporting Person (See Instructions):

IN

Consists of (i) 1,599,417 shares held directly by Ponoi LP (ii) 145,401 shares held directly by Ponoi II LP and (iii) 91 shares held directly by TCG LLC. Ponoi LLC is the general partner of Ponoi LP and may be deemed to have voting and investment power with respect to the shares held by Ponoi LP. Ponoi II LLC is the general partner of Ponoi II LP and may be deemed to have voting and investment power with respect to the shares held by Ponoi LP. The managing partners of each of Ponoi LLC, Ponoi II LLC and TCG LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to the shares held by each of Ponoi LP, Ponoi II LP and TCG LLC.

This calculation is based upon 29,488,367 shares of Common Stock outstanding as of August 6, 2021, as reported in the Form 10-Q.

Security and Issuer

Interest in Securities of the Issuer

Dated: August 30, 2021

THE COLUMN GROUP II, LP

THE COLUMN GROUP II GP, LP

By:

By:

/s/ James Evangelista, Attorney-in-Fact

By:

/s/ James Evangelista, Attorney-in-Fact

PONOI CAPITAL, LP

PONOI MANAGEMENT, LLC

By:

Ponoi Management, LLC

By:

/s/ James Evangelista, Attorney-in-Fact

By:

/s/ James Evangelista, Attorney-in-Fact

PONOI CAPITAL II, LP

PONOI II MANAGEMENT, LLC

By:

Ponoi II Management, LLC

By:

/s/ James Evangelista, Attorney-in-Fact

By:

/s/ James Evangelista, Attorney-in-Fact

THE COLUMN GROUP, LLC

By:

/s/ James Evangelista, Attorney-in-Fact

By:

/s/ James Evangelista, Attorney-in-Fact on behalf of Peter Svennilson

By:

/s/ James Evangelista, Attorney-in-Fact on behalf of Tim Kutzkey

By:

/s/ James Evangelista, Attorney-in-Fact on behalf of David V. Goeddel

Dated: August 30, 2021

THE COLUMN GROUP II, LP

THE COLUMN GROUP II GP, LP

By:

By:

/s/ James Evangelista, Attorney-in-Fact

By:

/s/ James Evangelista, Attorney-in-Fact

PONOI CAPITAL, LP

PONOI MANAGEMENT, LLC

By:

Ponoi Management, LLC

By:

/s/ James Evangelista, Attorney-in-Fact

By:

/s/ James Evangelista, Attorney-in-Fact

PONOI CAPITAL II, LP

PONOI II MANAGEMENT, LLC

By:

Ponoi II Management, LLC

By:

/s/ James Evangelista, Attorney-in-Fact

By:

/s/ James Evangelista, Attorney-in-Fact

THE COLUMN GROUP, LLC

By:

/s/ James Evangelista, Attorney-in-Fact

By:

/s/ James Evangelista, Attorney-in-Fact on behalf of Peter Svennilson

By:

/s/ James Evangelista, Attorney-in-Fact on behalf of Tim Kutzkey

By:

/s/ James Evangelista, Attorney-in-Fact on behalf of David V. Goeddel