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NAMES OF REPORTING PERSONS

Third Rock Ventures II, L.P.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ☐ (b) ☒

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

Accession Number:: 0001193125-21-044853
Form Type:: 13G Filing
Publication Date:: 2021-02-16 16:06:06

Filed By:: Third Rock Ventures Ii, L.p.
Company:: Jounce Therapeutics Inc.
Filing Date:: 2021-02-16
SEC Url:: 13G Filing

Ownership Summary

Please notice the below summary table is generated without human intervention and may contain errors. Please refer to the complete filing displayed below for exact figures.

Name	Sole Voting Power	Shared Voting Power	Sole Dispositive Power	Shared Dispositive Power	Aggregate Amount Owned Power	Percent of Class
Third Rock Ventures II	0	9,200,349	0	9,200,349	9,200,349	23.1%
Third Rock Ventures GP II	0	9,200,349	0	9,200,349	9,200,349	23.1%
TRV GP II	0	9,200,349	0	9,200,349	9,200,349	23.1%
Third Rock Ventures III	0	3,048,780	0	3,048,780	3,048,780	7.7%
Third Rock Ventures GP III	0	3,048,780	0	3,048,780	3,048,780	7.7%
TRV GP III	0	3,048,780	0	3,048,780	3,048,780	7.7%
Mark Levin	54,085	12,249,129	54,085	12,249,129	12,303,214	30.9%
Kevin Starr	53,592	12,249,129	53,592	12,249,129	12,302,721	30.9%
Robert I. Tepper	90,699	12,249,129	90,699	12,249,129	12,339,828	31.0%

Filing

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1 )*

Jounce Therapeutics, Inc.

(Name of Issuer)

COMMON STOCK, $0.001 PAR VALUE PER SHARE

(Title of Class of Securities)

481116101

(CUSIP Number)

December 31, 2020

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☐ Rule 13d-1(c)

☒ Rule 13d-1(d)

*	The remainder of this cover page shall be filled out for a reporting persons initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be filed for the purpose of Section 18 of the Securities Exchange Act of 1934 (Act) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).


CUSIP No. 481116101		SCHEDULE 13G		Page 2 of 15 Pages

(1)	The percent of class was calculated based on 39,851,475 shares of common stock issued and outstanding as of November 2, 2020, as disclosed in the Issuers Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020.


CUSIP No. 481116101		SCHEDULE 13G		Page 3 of 15 Pages

(1)	The percent of class was calculated based on 39,851,475 shares of common stock issued and outstanding as of November 2, 2020, as disclosed in the Issuers Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020.


CUSIP No. 481116101		SCHEDULE 13G		Page 4 of 15 Pages

(1)	The percent of class was calculated based on 39,851,475 shares of common stock issued and outstanding as of November 2, 2020, as disclosed in the Issuers Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020.


CUSIP No. 481116101		SCHEDULE 13G		Page 5 of 15 Pages

(1)	The percent of class was calculated based on 39,851,475 shares of common stock issued and outstanding as of November 2, 2020, as disclosed in the Issuers Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020.


CUSIP No. 481116101		SCHEDULE 13G		Page 6 of 15 Pages

(1)	The percent of class was calculated based on 39,851,475 shares of common stock issued and outstanding as of November 2, 2020, as disclosed in the Issuers Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020.


CUSIP No. 481116101		SCHEDULE 13G		Page 7 of 15 Pages

(1)	The percent of class was calculated based on 39,851,475 shares of common stock issued and outstanding as of November 2, 2020, as disclosed in the Issuers Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020.


CUSIP No. 481116101		SCHEDULE 13G		Page 8 of 15 Pages

(1)	The percent of class was calculated based on 39,851,475 shares of common stock issued and outstanding as of November 2, 2020, as disclosed in the Issuers Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020.


CUSIP No. 481116101		SCHEDULE 13G		Page 9 of 15 Pages

(1)	The percent of class was calculated based on 39,851,475 shares of common stock issued and outstanding as of November 2, 2020, as disclosed in the Issuers Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020.


CUSIP No. 481116101		SCHEDULE 13G		Page 10 of 15 Pages

(1)	This number includes 37,100 shares of common stock issuable to Dr. Tepper upon exercise of options exercisable within 60 days of December 31, 2020.

(2)

The percent of class was calculated based on 39,851,475 shares of common stock issued and outstanding as of November 2, 2020, as disclosed in the Issuers Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020 and 37,100 shares of common stock underlying the options that are exercisable within 60 days of December 31, 2020 which are deemed outstanding pursuant to SEC Rule 13-3(d)(1)(i)).


CUSIP No. 481116101		SCHEDULE 13G		Page 11 of 15 Pages

Item 1.

Issuer

(a)

Name of Issuer:

Jounce Therapeutics, Inc. (the Issuer)

(b)

Address of Issuers Principal Executive Offices:

780 Memorial Drive

Cambridge, Massachusetts 02139

Item 2.

Filing Person

(a) (c) Name of Persons Filing; Address; Citizenship:

(i)

Third Rock Ventures II, L.P. (TRV II);

(ii)

Third Rock Ventures GP II, L.P. (TRV GP II), which is the sole general partner of TRV II;

(iii)

TRV GP II, LLC (TRV GP II LLC), which is the sole general partner of TRV GP II;

(iv)

Third Rock Ventures III, L.P. (TRV III);

(v)

Third Rock Ventures GP III, L.P. (TRV GP III), which is the sole general partner of TRV III;

(vi)

TRV GP III, LLC (TRV GP III LLC), which is the sole general partner of TRV GP III;

(vii)

Mark Levin (Levin), a managing member of TRV GP II LLC and TRV GP III LLC;

(viii)

Kevin P. Starr (Starr), a managing member of TRV GP II LLC and TRV GP III LLC; and

(ix)

Robert I. Tepper (Tepper, and collectively with TRV II, TRV GP II, TRV GP II LLC, TRV III, TRV GP III, TRV GP III LLC, Levin and Starr, the Reporting Persons), a managing member of TRV GP II LLC and TRV GP III LLC.

The address of the principal business office of each of the Reporting Persons is Third Rock Ventures, LLC, 29 Newbury Street, 3rd Floor, Boston, MA 02116.

Each of TRV II, TRV GP II, TRV III and TRV GP III is a Delaware limited partnership. Each of TRV GP II LLC and TRV GP III LLC is a Delaware limited liability company. Levin, Tepper and Starr are United States citizens.

(d)

Title of Class of Securities:

Common stock, $0.001 par value per share, (the Common Stock)

(e)

CUSIP Number:

481116101

Item 3.

If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:


(a)	☐	Broker or dealer registered under Section 15 of the Act;

(b)	☐	Bank as defined in Section 3(a)(6) of the Act;

(c)	☐	Insurance company as defined in Section 3(a)(19) of the Act;

(d)	☐	Investment company registered under Section 8 of the Investment Company Act of 1940;

(e)	☐	An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

(f)	☐	An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F);

(g)	☐	A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G);


CUSIP No. 481116101		SCHEDULE 13G		Page 12 of 15 Pages


(h)	☐	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)	☐	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940;

(j)	☐	A non-U.S. institution in accordance with Rule 240.13d-1(b)(1)(ii)(J);

(k)	☐	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with Rule 240.13d-1(b)(1)(ii)(J), please specify the type of institution:

	If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution:

Item 4.

Ownership.

(a) and (b) Amount beneficially owned:

(i)

TRV II directly owns 9,200,349 shares of Common Stock (the Fund II Shares), which represents approximately 23.1% of the outstanding shares of Common Stock.

(ii)

TRV GP II is the general partner of TRV II and may be deemed to beneficially own the Fund II Shares.

(iii)

TRV GP II LLC is the general partner of TRV GP II and may be deemed to beneficially own the Fund II Shares.

(iv)

TRV III directly owns 3,048,780 shares of Common Stock (the Fund III Shares), which represents approximately 7.7% of the outstanding shares of Common Stock.

(v)

TRV GP III is the general partner of TRV III and may be deemed to beneficially own the Fund III Shares.

(vi)

TRV GP III LLC is the general partner of TRV GP III and may be deemed to beneficially own the Fund III Shares.

(vii)

As a managing member of TRV GP II LLC and TRV GP III LLC, Levin may be deemed to beneficially own the Fund II Shares and the Fund III Shares. Additionally, Levin directly owns 54,085 shares of Common Stock.

(viii)

As a managing member of TRV GP II LLC and TRV GP III LLC, Tepper may be deemed to beneficially own the Fund II Shares and the Fund III Shares. Additionally, Tepper directly owns 53,599 shares of Common Stock and options to purchase 37,100 shares of common stock exercisable within 60 days of December 31, 2020.

(ix)

As a managing member of TRV GP II LLC and TRV GP III LLC, Starr may be deemed to beneficially own the Fund II Shares and the Fund III Shares. Additionally, Starr directly owns 53,592 shares of Common Stock.

(c)

Number of shares as to which such person has:


CUSIP No. 481116101		SCHEDULE 13G		Page 13 of 15 Pages


	Number of Shares of Common Stock
Reporting Person	(i)		(ii)		(iii)		(iv)
TRV II		0		9,200,349		0		9,200,349
TRV GP II		0		9,200,349		0		9,200,349
TRV GP II LLC		0		9,200,349		0		9,200,349
TRV III		0		3,048,780		0		3,048,780
TRV GP III		0		3,048,780		0		3,048,780
TRV GP III LLC		0		3,048,780		0		3,048,780
Levin		54,085		12,249,129		54,085		12,249,129
Starr		53,592		12,249,129		53,592		12,249,129
Tepper		90,699		12,249,129		90,699		12,249,129

(i)

Sole power to vote or direct the vote

(ii)

Shared power to vote or to direct the vote

(iii)

Sole power to dispose or to direct the disposition of

(iv)

Shared power to dispose or to direct the disposition of

Item 5.

Ownership of Five Percent or Less of a Class.

Not applicable.

Item 6.

Ownership of More than Five Percent on Behalf of Another Person.

Not applicable.

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

Not applicable.

Item 8.

Identification and Classification of Members of the Group.

Not applicable.

Item 9.

Notice of Dissolution of Group.

Not applicable.

Item 10.

Certification.

Not applicable.


CUSIP No. 481116101		SCHEDULE 13G		Page 14 of 15 Pages

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: February 16, 2021


THIRD ROCK VENTURES II, L.P.

By: THIRD ROCK VENTURES GP II, L.P.,
General Partner

By: TRV GP II, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

THIRD ROCK VENTURES GP II, L.P.

By: TRV GP II, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

TRV GP II, LLC

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

THIRD ROCK VENTURES III, L.P.

By: THIRD ROCK VENTURES GP III, L.P.,
General Partner

By: TRV GP III, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer


CUSIP No. 481116101		SCHEDULE 13G		Page 15 of 15 Pages


THIRD ROCK VENTURES GP III, L.P.

By: TRV GP III, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

TRV GP III, LLC

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

MARK LEVIN

/s/ Kevin Gillis, As attorney-in-fact
Mark Levin

KEVIN P. STARR

/s/ Kevin Gillis, As attorney-in-fact
Kevin P. Starr

ROBERT I. TEPPER

/s/ Kevin Gillis, As attorney-in-fact
Robert I. Tepper

EXHIBIT 24

POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS, that the undersigned hereby constitutes and appoints Kevin Gillis his true and lawful attorney-in-fact, with full power of substitution, to sign any and all instruments, certificates and documents that may be necessary, desirable or appropriate to be executed on behalf of himself as an individual or in his capacity as a direct or indirect general partner, director, officer, member or manager of any partnership, corporation or limited liability company, pursuant to section 13 or 16 of the Securities Exchange Act of 1934, as amended (the Exchange Act), and any and all regulations promulgated thereunder, and to file the same, with all exhibits thereto, and any other documents in connection therewith, with the Securities and Exchange Commission, and with any other entity when and if such is mandated by the Exchange Act or by the Financial Industry Regulatory Authority, granting unto said attorney-in-fact full power and authority to do and perform each and every act and thing necessary, desirable or appropriate, fully to all intents and purposes as he might or could do in person, thereby ratifying and confirming all that said attorney-in-fact, or his substitutes, may lawfully do or cause to be done by virtue hereof. Each of the undersigned may execute this power of attorney in separate counterparts, and each counterpart shall be deemed to be an original instrument. This agreement shall be effective as to each of the undersigned as of the date signed by that signatory.

IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 16th day of January, 2014.

/s/ Mark Levin

Mark Levin

/s/ Kevin P. Starr

Kevin P. Starr

/s/ Robert I. Tepper

Robert I. Tepper

EXHIBIT 99.1

Joint Filing Agreement

The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained herein, but shall not be responsible for the completeness and accuracy of the information concerning the other entities or persons, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate.

Dated: February 16, 2021


THIRD ROCK VENTURES II, L.P.

By: THIRD ROCK VENTURES GP II, L.P.,
General Partner

By: TRV GP II, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

THIRD ROCK VENTURES GP II, L.P.

By: TRV GP II, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

TRV GP II, LLC

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

THIRD ROCK VENTURES III, L.P.

By: THIRD ROCK VENTURES GP III, L.P.,
General Partner

By: TRV GP III, LLC,
General Partner


By:		/s/ Kevin Gillis
Kevin Gillis
Chief Financial Officer

THIRD ROCK VENTURES GP III, L.P.

By: TRV GP III, LLC,
General Partner

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

TRV GP III, LLC

By:		/s/ Kevin Gillis
Kevin Gillis
Chief Operating Officer

MARK LEVIN

/s/ Kevin Gillis, As attorney-in-fact
Mark Levin

KEVIN P. STARR

/s/ Kevin Gillis, As attorney-in-fact
Kevin P. Starr

ROBERT I. TEPPER

/s/ Kevin Gillis, As attorney-in-fact
Robert I. Tepper