Filing Details

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

SCHEDULE 13G/A

 

Under the Securities Exchange Act of 1934

(Amendment No. 1)

 

Epizyme, Inc

(Name of Issuer)

 

Common Stock, $0.0001 par value

(Title of Class of Securities)

 

29428V104

(CUSIP Number)

 

December 31, 2019

(Date of Event Which Requires Filing of this Statement)

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

 

o       Rule 13d-1(b)

 

þ       Rule 13d-1(c)

 

o       Rule 13d-1(d)

 

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

 

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

 

CUSIP No. 29428V104

1	Name of Reporting Person   Redmile Group, LLC
2	Check the Appropriate Box if a Member of a Group (See Instructions)   (a) ¨   (b) ¨
3	SEC Use Only
4	Citizenship or Place of Organization   Delaware
number of shares beneficially owned by each reporting person with		5	Sole Voting Power   0
		6	Shared Voting Power   9,137,373(1)
		7	Sole Dispositive Power   0
		8	Shared Dispositive Power   9,137,373(1)
9	Aggregate Amount Beneficially Owned by Each Reporting Person   9,137,373(1)
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11	Percent of Class Represented by Amount in Row (9)   9.9%(2)
12	Type of Reporting Person (See Instructions)   IA, OO

 

⁽¹⁾ Redmile Group, LLC’s beneficial ownership of the Issuer’s common stock (“Common Stock”) is comprised of 8,746,033 shares of Common Stock owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles and/or separately managed accounts. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Subject to the Beneficial Ownership Blocker (as defined below), Redmile Group, LLC may also be deemed to beneficially own an aggregate of 350,000 shares of Series A Convertible Preferred Stock (“Series A Preferred Stock”), which are convertible into an aggregate of 3,500,000 shares of Common Stock. Pursuant to the Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock (the “Certificate of Designation”), the Issuer may not effect any conversion of the Series A Preferred Stock, and a holder of the Series A Preferred Stock does not have the right to convert any portion of the Series A Preferred Stock held by such holder, to the extent that, after giving effect to the attempted conversion set forth in a notice of conversion, such holder, together with such holder’s affiliates and any other person whose beneficial ownership of Common Stock would be aggregated with such holder’s for purposes of Section 13(d) or Section 16 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and the applicable regulations of the Securities and Exchange Commission (the “SEC”), including any “group” of which such holder is a member, would beneficially own a number of shares of Common Stock in excess of the Beneficial Ownership Limitation (the “Beneficial Ownership Blocker”). The “Beneficial Ownership Limitation” is 9.99% of the shares of Common Stock then issued and outstanding, which percentage may be changed at a holder’s election upon 61 days’ notice to the Issuer. The 9,137,373 shares of Common Stock reported as beneficially owned by Redmile Group, LLC in this Schedule 13G represents 9.99% of the outstanding shares of Common Stock (calculated in accordance with footnote (2) below).

 

⁽²⁾ Percentage based on: (i) 91,073,942 shares of Common Stock issued and outstanding as of October 25, 2019, as reported by the Issuer in its Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2019 filed with the SEC on October 31, 2019 (the “Form 10-Q”), plus (ii) 393,140 shares of Common Stock issuable upon conversion of 39,134 shares of Series A Preferred Stock, which, due to the Beneficial Ownership Limitation, is the maximum number of shares of Series A Preferred Stock that could be converted to Common Stock as of October 25, 2019.

 

 

CUSIP No. 29428V104

1	Name of Reporting Person   Jeremy C. Green
2	Check the Appropriate Box if a Member of a Group (See Instructions)   (a) ¨   (b) ¨
3	SEC Use Only
4	Citizenship or Place of Organization   United Kingdom
number of shares beneficially owned by each reporting person with		5	Sole Voting Power   0
		6	Shared Voting Power   9,137,373(3)
		7	Sole Dispositive Power   0
		8	Shared Dispositive Power   9,137,373(3)
9	Aggregate Amount Beneficially Owned by Each Reporting Person   9,137,373(3)
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11	Percent of Class Represented by Amount in Row (9)   9.9%(4)
12	Type of Reporting Person (See Instructions)   IN, HC

 

⁽³⁾ Jeremy C. Green’s beneficial ownership of Common Stock is comprised of 8,746,033 shares of Common Stock owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles and/or separately managed accounts. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Subject to the Beneficial Ownership Blocker, Mr. Green may also be deemed to beneficially own an aggregate of 350,000 shares of Series A Preferred Stock, which are convertible into an aggregate of 3,500,000 shares of Common Stock. Pursuant to the Certificate of Designation, the Issuer may not effect any conversion of the Series A Preferred Stock, and a holder of the Series A Preferred Stock does not have the right to convert any portion of the Series A Preferred Stock held by such holder, if the Beneficial Ownership Blocker applies. The 9,137,373 shares of Common Stock reported as beneficially owned by Redmile Group, LLC in this Schedule 13G represents 9.99% of the outstanding shares of Common Stock (calculated in accordance with footnote (4) below).

 

⁽⁴⁾ Percentage based on: (i) 91,073,942 shares of Common Stock issued and outstanding as of October 25, 2019, as reported by the Issuer in the Form 10-Q, plus (ii) 393,140 shares of Common Stock issuable upon conversion of 39,134 shares of Series A Preferred Stock, which, due to the Beneficial Ownership Limitation, is the maximum number of shares of Series A Preferred Stock that could be converted to Common Stock as of October 25, 2019.

 

 

CUSIP No. 29428V104

1	Name of Reporting Person   Redmile Capital Offshore Master Fund, Ltd.
2	Check the Appropriate Box if a Member of a Group (See Instructions)   (a) ¨   (b) ¨
3	SEC Use Only
4	Citizenship or Place of Organization   Cayman Islands
number of shares beneficially owned by each reporting person with		5	Sole Voting Power   0
		6	Shared Voting Power   5,268,879(5)
		7	Sole Dispositive Power   0
		8	Shared Dispositive Power   5,268,879(3)
9	Aggregate Amount Beneficially Owned by Each Reporting Person   5,268,879(3)
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11	Percent of Class Represented by Amount in Row (9)   5.7%(6)
12	Type of Reporting Person (See Instructions)   CO

  

⁽⁵⁾ Redmile Capital Offshore Master Fund, Ltd.’s beneficial ownership of Common Stock is comprised of 3,822,879 shares of Common Stock and 1,446,000 shares of Common Stock issuable upon conversion of shares of Series A Preferred Stock held directly by Redmile Capital Offshore Master Fund, Ltd. Pursuant to the Certificate of Designation, the Issuer may not effect any conversion of the Series A Preferred Stock, and a holder of the Series A Preferred Stock does not have the right to convert any portion of the Series A Preferred Stock held by such holder, if the Beneficial Ownership Blocker applies. The 5,268,879 shares of Common Stock reported as beneficially owned by Redmile Capital Offshore Master Fund, Ltd. in this Schedule 13G does not account for shares of Common Stock beneficially owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC. If Redmile Group, LLC and its affiliates are beneficial owners of greater than 9.99% of the number of Common Stock outstanding, then the number of shares of Series A Preferred Stock currently convertible by Redmile Capital Offshore Master Fund, Ltd. will be reduced and such shares of Common Stock issuable upon conversion thereof will not be deemed beneficially owned by Redmile Capital Offshore Master Fund, Ltd. The 5,268,879 shares of Common Stock reported as beneficially owned by Redmile Capital Offshore Master Fund, Ltd. in this Schedule 13G represents 5.7% of the outstanding shares of Common Stock (calculated in accordance with footnote (8) below). Redmile Capital Offshore Master Fund, Ltd. is managed by Redmile Group, LLC, and the shares of Common Stock beneficially owned by Redmile Capital Offshore Master Fund, Ltd. may be deemed beneficially owned by Redmile Group, LLC as investment manager of Redmile Capital Offshore Master Fund, Ltd. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any.

 

⁽⁶⁾ Percentage based on: (i) 91,073,942 shares of Common Stock issued and outstanding as of October 25, 2019, as reported by the Issuer in the Form 10-Q, plus (ii) 1,446,000 shares of Common Stock issuable upon conversion of 144,600 shares of Series A Preferred Stock held by Redmile Capital Offshore Master Fund, Ltd.

  

 

Item 1.

 

(a)

Name of Issuer

 

Epizyme, Inc.

 

(b)

Address of Issuer’s Principal Executive Offices

 

400 Technology Square

Cambridge, Massachusetts 02139

 

Item 2.

 

(a)

Names of Persons Filing

 

Redmile Group, LLC
Jeremy C. Green

 

(b)

Address of Principal Business office or, if None, Residence

 

Redmile Group, LLC
One Letterman Drive
Building D, Suite D3-300
The Presidio of San Francisco
San Francisco, California 94129

 

Jeremy C. Green
c/o Redmile Group, LLC
One Letterman Drive
Building D, Suite D3-300
The Presidio of San Francisco
San Francisco, California 94129

 

Redmile Capital Offshore Master Fund, Ltd.

c/o Redmile Group, LLC
One Letterman Drive
Building D, Suite D3-300
The Presidio of San Francisco
San Francisco, California 94129

 

(c)

Citizenship

 

Redmile Group, LLC: Delaware
Jeremy C. Green: United Kingdom

Redmile Capital Offshore Master Fund, Ltd.: Cayman Islands

 

(d)

Title of Class of Securities

 

Common Stock, $0.0001 par value

 

(e)

CUSIP Number

 

29428V104

 

 

Item 3.

If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

 

	(a)	¨	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);

(b)

¨

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

 

	(c)	¨	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);

	(d)	¨	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8);

(e)

¨

An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

 

	(f)	¨	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);

	(g)	¨	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

	(h)	¨	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

	(i)	¨	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

¨

A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J);

 

(k)

¨

Group, in accordance with § 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution: __________

 

Item 4.

Ownership.

 

(a)

Amount beneficially owned:

 

Redmile Group, LLC – 9,137,373 (1)
Jeremy C. Green – 9,137,373 (1)

Redmile Capital Offshore Master Fund, Ltd. – 5,268,879 (2)

 

(b)

Percent of class:

 

Redmile Group, LLC – 9.9% (3)
Jeremy C. Green – 9.9% (3)

Redmile Capital Offshore Master Fund, Ltd. – 5.7% (4)

 

(c)

Number of shares as to which Redmile Group, LLC has:

 

(i)

Sole power to vote or to direct the vote:

 

0

 

(ii)

Shared power to vote or to direct the vote:

 

9,137,373 (1)

 

(iii)

Sole power to dispose or to direct the disposition of:

 

0

 

 

(iv)

Shared power to dispose or to direct the disposition of:

 

9,137,373 (1)

 

Number of shares as to which Jeremy C. Green has:

 

(i)

Sole power to vote or to direct the vote:

 

0

 

(ii)

Shared power to vote or to direct the vote:

 

9,137,373 (1)

 

(iii)

Sole power to dispose or to direct the disposition of:

 

0

 

(iv)

Shared power to dispose or to direct the disposition of:

 

9,137,373 (1)

 

Number of shares as to which Redmile Capital Offshore Master Fund, Ltd. has:

 

(i)

Sole power to vote or to direct the vote:

 

0

 

(ii)

Shared power to vote or to direct the vote:

 

5,268,879 (2)

 

(iii)

Sole power to dispose or to direct the disposition of:

 

0

 

(iv)

Shared power to dispose or to direct the disposition of:

 

5,268,879 (2)

 

(1)

Redmile Group, LLC’s and Jeremy C. Green’s beneficial ownership of Common Stock is comprised of 8,746,033 shares of Common Stock owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles and/or separately managed accounts. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Subject to the Beneficial Ownership Blocker, Mr. Green may also be deemed to beneficially own an aggregate of 350,000 shares of Series A Preferred Stock, which are convertible into an aggregate of 3,500,000 shares of Common Stock.

 

(2)

Redmile Capital Offshore Master Fund, Ltd.’s beneficial ownership of Common Stock is comprised of 3,822,879 shares of Common Stock and 1,446,000 shares of Common Stock issuable upon conversion of shares of Series A Preferred Stock held directly by Redmile Capital Offshore Master Fund, Ltd.

 

(3)

Percentage based on: (i) 91,073,942 shares of Common Stock issued and outstanding as of October 25, 2019, as reported by the Issuer in the Form 10-Q, plus (ii) 393,140 shares of Common Stock issuable upon conversion of 39,134 shares of Series A Preferred Stock, which, due to the Beneficial Ownership Limitation, is the maximum number of shares of Series A Preferred Stock that could be converted to Common Stock as of October 25, 2019.

 

 

(4)

Percentage based on: (i) 91,073,942 shares of Common Stock issued and outstanding as of October 25, 2019, as reported by the Issuer in the Form 10-Q, plus (ii) 1,446,000 shares of Common Stock issuable upon conversion of 144,600 shares of Series A Preferred Stock held by Redmile Capital Offshore Master Fund, Ltd.

 

Item 5.

Ownership of Five Percent or Less of a Class.

 

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following ¨

 

Item 6.

Ownership of More than Five Percent on Behalf of Another Person.

 

N/A.

 

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

 

See Exhibit A attached hereto.

 

Item 8.

Identification and Classification of Members of the Group.

 

N/A

 

Item 9.

Notice of Dissolution of Group.

 

N/A

 

Item 10.

Certifications.

 

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

 

 

SIGNATURE

 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

 

Date: February 14, 2020

 

	Redmile Group, LLC
	By:	/s/ Jeremy C. Green
		Name: Jeremy C. Green Title: Managing Member
		/s/ Jeremy C. Green
		Jeremy C. Green
	Redmile Capital Offshore Master Fund Ltd.
	By: Redmile Group LLC, its investment manager
	By:	/s/ Jeremy C. Green
		Name: Jeremy C. Green
		Title: Managing Member

 

 

Exhibit A

 

Redmile Group, LLC is the relevant entity for which Jeremy C. Green may be considered a control person.