Filing Details
- Accession Number:
- 0001193125-20-033323
- Form Type:
- 13D Filing
- Publication Date:
- 2020-02-12 16:42:33
- Filed By:
- Polaris Venture Partners V, L.p.
- Company:
- Cartesian Therapeutics Inc.
- Filing Date:
- 2020-02-12
- SEC Url:
- 13D Filing
Please notice the below summary table is generated without human intervention and may contain errors. Please refer to the complete filing displayed below for exact figures.
| Name | Sole Voting Power | Shared Voting Power | Sole Dispositive Power | Shared Dispositive Power | Aggregate Amount Owned Power | Percent of Class |
|---|---|---|---|---|---|---|
| Polaris Venture Partners V | 2,676,234 | 2,676,234 | 2,676,234 | 3.1% | ||
| Polaris Venture Partners Entrepreneurs 146 Fund V | 52,156 | 52,156 | 52,156 | 0.1% | ||
| Polaris Venture Partners Founders 146 Fund V | 18,329 | 18,329 | 18,329 | 0.0% | ||
| Polaris Venture Partners Special Founders 146 Fund V | 26,760 | 26,760 | 26,760 | 0.0% | ||
| Polaris Venture Management Co. V | 2,773,479 | 2,773,479 | 2,773,479 | 3.2% | ||
| Jonathan A. Flint | 2,773,479 | 2,773,479 | 2,773,479 | 3.2% | ||
| Terrance G. McGuire | 2,773,479 | 2,773,479 | 2,773,479 | 3.2% | ||
| Amir Nashat | 2,789,889 | 2,789,889 | 2,789,889 | 3.2% |
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13D
Under the Securities Exchange Act of 1934
(Amendment No. 4)*
SELECTA BIOSCIENCES, INC.
(Name of Issuer)
Common Stock, $0.0001 par value
(Title of Class of Securities)
816212104
(CUSIP Number)
| Polaris Partners One Marina Park Drive, 10th Floor Boston, MA 02210 | Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP One Marina Park Drive, Suite 900 Boston, MA 02210 Attn: Jay K. Hachigian, Esq. (617) 648-9100 |
(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
December 23, 2019
(Date of Event which Requires Filing of this Statement)
If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box: ☐
Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties to whom copies are to be sent.
| * | The remainder of this cover page shall be filled out for a reporting persons initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. |
The information required on the remainder of this cover page shall not be deemed to be filed for the purpose of Section 18 of the Securities Exchange Act of 1934 (Act) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
| 1. | Names of Reporting Persons.
Polaris Venture Partners V, L.P. (PVP V) | |||||
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒
| |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
WC | |||||
| 5. | Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)
☐ | |||||
| 6. | Citizenship or Place of Organization
Delaware | |||||
| Number of Shares Beneficially Owned by Each Reporting Person With | 7. | Sole Voting Power
2,676,234 shares, except that (i) Polaris Venture Management Co. V, L.L.C. (PVM V), the general partner of PVP V, may be deemed to have sole power to vote these shares, and (ii) Jonathan A. Flint (Flint), a managing member of PVM V, may be deemed to have shared power to vote these shares, Terrance G. McGuire (McGuire), a managing member of PVM V, may be deemed to have shared power to vote these shares and Amir Nashat (Nashat), a member of PVM V and member of the Board of Directors of the Issuer, may be deemed to have shared power to vote these shares. | ||||
| 8. | Shared Voting Power
See response to row 7. | |||||
| 9. | Sole Dispositive Power
2,676,234 shares, except that (i) PVM V, the general partner of PVP V, may be deemed to have sole power to dispose of these shares, and (ii) Flint, a managing member of PVM V, may be deemed to have shared power to dispose of these shares, McGuire, a managing member of PVM V, may be deemed to have shared power to dispose of these shares and Nashat, a member of PVM V and member of the Board of Directors of the Issuer, maybe be deemed to have shared power to dispose of these shares. | |||||
| 10. | Shared Dispositive Power
See response to row 9. | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
2,676,234 | |||||
| 12. | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
3.1% | |||||
| 14. | Type of Reporting Person (See Instructions)
PN | |||||
| 1. | Names of Reporting Persons.
Polaris Venture Partners Entrepreneurs Fund V, L.P. (PVPE V) | |||||
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒
| |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
WC | |||||
| 5. | Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
☐ | |||||
| 6. | Citizenship or Place of Organization
Delaware | |||||
| Number of Shares Beneficially Owned by Each Reporting Person With | 7. | Sole Voting Power
52,156 shares, except that (i) PVM V, the general partner of PVPE V, may be deemed to have sole power to vote these shares, and (ii) Flint, a managing member of PVM V, may be deemed to have shared power to vote these shares, McGuire, a managing member of PVM V, may be deemed to have shared power to vote these shares and Nashat, a member of PVM V and member of the Board of Directors of the Issuer, may be deemed to have shared power to vote these shares. | ||||
| 8. | Shared Voting Power
See response to row 7. | |||||
| 9. | Sole Dispositive Power
52,156 shares, except that (i) PVM V, the general partner of PVPE V, may be deemed to have sole power to dispose of these shares, and (ii) Flint, a managing member of PVM V, may be deemed to have shared power to dispose of these shares, McGuire, a managing member of PVM V, may be deemed to have shared power to dispose of these shares, and Nashat, a member of PVM V and member of the Board of Directors of the Issuer, may be deemed to have shared power to dispose of these shares. | |||||
| 10. | Shared Dispositive Power
See response to Row 9. | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
52,156 | |||||
| 12. | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
0.1% | |||||
| 14. | Type of Reporting Person (See Instructions)
PN | |||||
| 1. | Names of Reporting Persons.
Polaris Venture Partners Founders Fund V, L.P. (PVPFF V) | |||||
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒
| |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
WC | |||||
| 5. | Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
☐ | |||||
| 6. | Citizenship or Place of Organization
Delaware | |||||
| Number of Shares Beneficially Owned by Each Reporting Person With | 7. | Sole Voting Power
18,329 shares, except that (i) PVM V, the general partner of PVPFF V, may be deemed to have sole power to vote these shares, and (ii) Flint, a managing member of PVM V, may be deemed to have shared power to vote these shares, McGuire, a managing member of PVM V, may be deemed to have shared power to vote these shares, and Nashat, a member of PVM V and member of the Board of Directors of the Issuer, may be deemed to have shared power to vote these shares. | ||||
| 8. | Shared Voting Power
See response to row 7. | |||||
| 9. | Sole Dispositive Power
18,329 shares, except that (i) PVM V, the general partner of PVPFF V, may be deemed to have sole power to dispose of these shares, and (ii) Flint, a managing member of PVM V, may be deemed to have shared power to dispose of these shares, McGuire, a managing member of PVM V, may be deemed to have shared power to dispose of these shares, and Nashat, a member of PVM V and member of the Board of Directors of the Issuer, may be deemed to have shared power to dispose of these shares. | |||||
| 10. | Shared Dispositive Power
See response to Row 9. |
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
18,329 | |||||
| 12. | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row
(11)
0.0% | |||||
| 14. | Type of Reporting Person (See
Instructions)
PN | |||||
| 1. | Names of Reporting Persons.
Polaris Venture Partners Special Founders Fund V, L.P. (PVPSFF V) | |||||
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒
| |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
WC | |||||
| 5. | Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
☐ | |||||
| 6. | Citizenship or Place of Organization
Delaware | |||||
| Number of Shares Beneficially Owned by Each Reporting Person With | 7. | Sole Voting Power
26,760 shares, except that (i) PVM V, the general partner of PVPSFF V, may be deemed to have sole power to vote these shares, and (ii) Flint, a managing member of PVM V, may be deemed to have shared power to vote these shares, McGuire, a managing member of PVM V, may be deemed to have shared power to vote these shares, and Nashat, a member of PVM V and member of the Board of Directors of the Issuer, may be deemed to have shared power to vote these shares. | ||||
| 8. | Shared Voting Power
See response to row 7. | |||||
| 9. | Sole Dispositive Power
26,760 shares, except that (i) PVM V, the general partner of PVPSFF V, may be deemed to have sole power to dispose of these shares, and (ii) Flint, a managing member of PVM V, may be deemed to have shared power to dispose of these shares, McGuire, a managing member of PVM V, may be deemed to have shared power to dispose of these shares, and Nashat, a member of PVM V and member of the Board of Directors of the Issuer, may be deemed to have shared power to dispose of these shares. | |||||
| 10. | Shared Dispositive Power
See response to row 9. |
| 11. | Aggregate Amount Beneficially Owned by Each Reporting
Person
26,760 | |||||
| 12. | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row
(11)
0.0% | |||||
| 14. | Type of Reporting Person (See
Instructions)
PN | |||||
| 1. | Names of Reporting Persons.
Polaris Venture Management Co. V, L.L.C. (PVM V) | |||||
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒
| |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
AF | |||||
| 5. | Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or
2(e)
☐ | |||||
| 6. | Citizenship or Place of
Organization
Delaware | |||||
| Number of Shares Beneficially Owned by Each Reporting Person With | 7. | Sole Voting Power
2,773,479 shares, of which (a) 2,676,234 shares are directly owned by PVP V, (b) 52,156 shares are directly owned by PVPE V, (c) 18,329 shares are directly owned by PVPFF and (d) 26,760 shares are directly owned by PVPSFF V, except that Flint, a managing member of PVM V, the general partner of each of PVP V, PVPE V, PVPFF V and PVPSFF V, may be deemed to have shared power to vote PVP Vs, PVPE Vs, PVPFF Vs and PVPSFF Vs shares (collectively, the Fund V Shares) shares, McGuire, a managing member of PVM V, may be deemed to have shared power to vote the Fund V Shares, and Nashat, a member of PVM V and member of the Board of Directors of the Issuer, may be deemed to have shared power to vote the Fund V Shares. | ||||
| 8. | Shared Voting Power
See response to row 7. | |||||
| 9. | Sole Dispositive Power
2,773,479 shares, of which (a) 2,676,234 shares are directly owned by PVP V, (b) 52,156 shares are directly owned by PVPE V, (c) 18,329 shares are directly owned by PVPFF and (d) 26,760 shares are directly owned by PVPSFF V, except that Flint, a managing member of PVM V, the general partner of each of PVP V, PVPE V, PVPFF V and PVPSFF V, may be deemed to have shared power to dispose of the Fund V Shares, McGuire, a managing member of PVM V, may be deemed to have shared power to dispose of the Fund V Shares, and Nashat, a member of PVM V and member of the Board of Directors of the Issuer, may be deemed to have shared power to dispose of the Fund V Shares. | |||||
| 10. | Shared Dispositive Power
See response to row 9. |
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
2,773,479 | |||||
| 12. | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row
(11)
3.2% | |||||
| 14. | Type of Reporting Person (See
Instructions)
OO | |||||
| 1. | Names of Reporting Persons.
Jonathan A. Flint | |||||
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒
| |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
AF | |||||
| 5. | Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
☐ | |||||
| 6. | Citizenship or Place of Organization
USA | |||||
| Number of Shares Beneficially Owned by Each Reporting Person With | 7. | Sole Voting Power
2,773,479 shares, of which (a) 2,676,234 shares are directly owned by PVP V, (b) 52,156 shares are directly owned by PVPE V, (c) 18,329 shares are directly owned by PVPFF and (d) 26,760 shares are directly owned by PVPSFF V, except that PVM V, the general partner of PVP V, PVPE V, PVPFF V and PVPSFF V, may be deemed to have sole power to vote the Fund V Shares, McGuire, as a managing member of PVM V, may be deemed to have shared power to vote the Fund V Shares, and Nashat, a member of PVM V, may be deemed to have shared power to vote the Fund V Shares. | ||||
| 8. | Shared Voting Power
See response to row 7. | |||||
| 9. | Sole Dispositive Power
2,773,479 shares, of which (a) 2,676,234 shares are directly owned by PVP V, (b) 52,156 shares are directly owned by PVPE V, (c) 18,329 shares are directly owned by PVPFF and (d) 26,760 shares are directly owned by PVPSFF V, except that PVM V, as general partner of PVP V, PVPE V, PVPFF V and PVPSFF V, maybe deemed to have sole power to dispose of the Fund V Shares, McGuire, as a managing member of PVM V, may be deemed to have shared power to dispose of the Fund V Shares, and Nashat, a member of PVM V, may be deemed to have shared power to dispose of the Fund V Shares. | |||||
| 10. | Shared Dispositive Power
See response to row 9. | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
2,773,479 | |||||
| 12. | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
3.2% | |||||
| 14. | Type of Reporting Person (See Instructions)
IN | |||||
| 1. | Names of Reporting Persons.
Terrance G. McGuire | |||||
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒
| |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
AF | |||||
| 5. | Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
☐ | |||||
| 6. | Citizenship or Place of Organization
USA | |||||
| Number of Shares Beneficially Owned by Each Reporting Person With | 7. | Sole Voting Power
2,773,479 shares, of which (a) 2,676,234 shares are directly owned by PVP V, (b) 52,156 shares are directly owned by PVPE V, (c) 18,329 shares are directly owned by PVPFF and (d) 26,760 shares are directly owned by PVPSFF V, except that PVM V, the general partner of PVP V, PVPE V, PVPFF V and PVPSFF V, may be deemed to have sole power to vote the Fund V Shares, Flint, as a managing member of PVM V, may be deemed to have shared power to vote the Fund V Shares, and Nashat, a member of PVM V, may be deemed to have shared power to vote the Fund V Shares. | ||||
| 8. | Shared Voting Power
See response to row 7. | |||||
| 9. | Sole Dispositive Power
2,773,479 shares, of which (a) 2,676,234 shares are directly owned by PVP V, (b) 52,156 shares are directly owned by PVPE V, (c) 18,329 shares are directly owned by PVPFF and (d) 26,760 shares are directly owned by PVPSFF V, except that PVM V, as general partner of PVP V, PVPE V, PVPFF V and PVPSFF V, may be deemed to have sole power to dispose of the Fund V Shares, Flint, as a managing member of PVM V, may be deemed to have shared power to dispose of the Fund V Shares, and Nashat, a member of PVM V, may be deemed to have shared power to dispose of the Fund V Shares. | |||||
| 10. | Shared Dispositive Power
See response to row 9. | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
2,773,479 | |||||
| 12. | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
3.2% | |||||
| 14. | Type of Reporting Person (See Instructions)
IN | |||||
| 1. | Names of Reporting Persons.
Amir Nashat | |||||
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒
| |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
AF | |||||
| 5. | Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
☐ | |||||
| 6. | Citizenship or Place of Organization
USA | |||||
| Number of Shares Beneficially Owned by Each Reporting Person With | 7. | Sole Voting Power
2,789,889 shares, of which (a) 2,676,234 shares are directly owned by PVP V, (b) 52,156 shares are directly owned by PVPE V, (c) 18,329 shares are directly owned by PVPFF, (d) 26,760 shares are directly owned by PVPSFF V and (e) 16,410 shares which represent Common Stock underlying a Stock Option owned by Nashat directly, except that PVM V, the general partner of PVP V, PVPE V, PVPFF V and PVPSFF V, may be deemed to have sole power to vote the Fund V Shares, Flint, as a managing member of PVM V, may be deemed to have shared power to vote the Fund V Shares, and McGuire, a managing member of PVM V, may be deemed to have shared power to vote the Fund V Shares. | ||||
| 8. | Shared Voting Power
See response to row 7. | |||||
| 9. | Sole Dispositive Power
2,789,889 shares, of which (a) 2,676,234 shares are directly owned by PVP V, (b) 52,156 shares are directly owned by PVPE V, (c) 18,329 shares are directly owned by PVPFF, (d) 26,760 shares are directly owned by PVPSFF V and (e) 16,410 shares which represent Common Stock underlying a Stock Option owned by Nashat directly, except that PVM V, as general partner of PVP V, PVPE V, PVPFF V and PVPSFF V, may be deemed to have sole power to dispose of the Fund V Shares, Flint, as a managing member of PVM V, may be deemed to have shared power to dispose of the Fund V Shares, and McGuire, a managing member of PVM V, may be deemed to have shared power to dispose of the Fund V Shares. | |||||
| 10. | Shared Dispositive Power
See response to row 9. | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
2,789,889 | |||||
| 12. | Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
3.2% | |||||
| 14. | Type of Reporting Person (See Instructions)
IN | |||||
CUSIP No. 816212104
SCHEDULE 13D
This Amendment No. 4 (Amendment No. 4) amends and supplements the Schedule 13D originally filed with the Securities and Exchange Commission (the SEC) on July 7, 2016 and amended on September 29, 2017 , May 3, 2018 and February 4, 2019 (collectively, the Schedule 13D) by the Reporting Persons. The Reporting Persons are, collectively, Polaris Venture Partners V, L.P. (PVP V), Polaris Venture Partners Entrepreneurs Fund V, L.P. (PVPE V), Polaris Venture Partners Founders Fund V, L.P (PVPFF V), Polaris Venture Partners Special Founders Fund, L.P. (PVPSFF V), Polaris Venture Management Co. V, L.L.C. (PVM V), Jonathan A. Flint (Flint), Terrance G. McGuire (McGuire) and Amir Nashat (Nashat). The Reporting Persons are making this single, joint filing because they may be deemed to constitute a group within the meaning of Section 13(d)(3) of the Securities Exchange Act of 1934, as amended. The agreement between the Reporting Persons to file as a group (the Joint Filing Agreement) is attached hereto as Exhibit A.
This Amendment No. 4 is being filed to report that the Reporting Persons have ceased to be the beneficial owners of more than 5% of the class of securities as of December 23, 2019. Only those items that are hereby reported are amended; all other items reported in the Schedule 13D remain unchanged. Information given in response to each item below shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms used herein but not defined shall have the meanings ascribed thereto in the Schedule 13D.
Item 5. Interest in Securities of the Issuer.
Item 5(a) of the Schedule 13D is hereby amended and restated in its entirety as follows:
The information in the cover page of each Reporting Person, except Nashat is based on a total of 86,325,547 shares of the Issuers Common Stock outstanding as of December 23, 2019 as reported on the Issuers Registration Statement on Form S-3 and filed with the United States Securities and Exchange Commission on January 29, 2020.
The information in the cover page of Nashat is based on a total of 86,341,957 shares, comprised of (i) 86,325,547 shares of the Issuers Common Stock outstanding as of December 23, 2019 as reported on the Issuers Registration Statement on Form S-3 and filed with the United States Securities and Exchange Commission on January 29, 2020, plus (ii) 16,410 shares of the Issuers Common Stock underlying fully vested stock options issued to Nashat for service as a member of the Issuers Board of Directors.
| (a) | Regarding aggregate beneficial ownership, see Row 11 of the cover page of each Reporting Person. Regarding percentage of class of beneficial ownership, see Row 13 of the cover page of each Reporting Person. Regarding sole power to vote shares, see Row 7 of the cover page of each Reporting Person. Regarding shared power to vote shares, see Row 8 of the cover page of each Reporting Person. Regarding sole power to dispose of shares, see Row 9 of the cover page of each Reporting Person. Regarding shared power to dispose of shares, see Row 10 of the cover page of each Reporting Person. |
| (c) | Except as described in this statement and below, none of the Reporting Persons has effected any transactions in the Common Stock in the 60 days prior to December 23, 2019. |
Each of the Reporting Persons ceased to be that beneficial owner of more than five percent of the Issuers Common Stock on December 23, 2019.
Item 7. Material to be Filed as Exhibits.
Exhibit A - Joint Filing Agreement
Exhibit E - Power of Attorney (Amir Nashat)
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: February 12, 2020
| POLARIS VENTURE PARTNERS V, L.P. | ||
| By: | Polaris Venture Management Co. V, L.L.C. | |
| By: | * | |
| Managing Member | ||
| POLARIS VENTURE PARTNERS ENTREPRENEURS FUND V, L.P. | ||
| By: | Polaris Venture Management Co. V, L.L.C. | |
| By: | * | |
| Managing Member | ||
| POLARIS VENTURE PARTNERS FOUNDERS FUND V, L.P. | ||
| By: | Polaris Venture Management Co. V, L.L.C. | |
| By: | * | |
| Managing Member | ||
| POLARIS VENTURE PARTNERS SPECIAL FOUNDERS FUND V, L.P. | ||
| By: | Polaris Venture Management Co. V, L.L.C. | |
| By: | * | |
| Managing Member | ||
| POLARIS VENTURE MANAGEMENT CO. V, L.L.C. | ||
| By: | * | |
| Managing Member | ||
| JONATHAN A. FLINT | ||
| By: | * | |
| Jonathan A. Flint | ||
| TERRANCE G. MCGUIRE | ||
| By: | * | |
| Terrance G. McGuire | ||
| AMIR NASHAT | ||
| By: | * | |
| Amir Nashat | ||
| *By: | /s/ Lauren Crockett | |
| Name: | Lauren Crockett | |
| Attorney-in-Fact |
[This Schedule 13D Amendment No. 4 was executed pursuant to Powers of Attorney. Note that copies of the applicable Powers of Attorney for the Reporting Persons other than Nashat are already on file with the appropriate agencies. The Power of Attorney of Amir Nashat is attached hereto as Exhibit E.]