Filing Details

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

The remainder of this cover page shall be filled out for a reporting persons initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The CUSIP number is for the American Depositary Shares that trade on the NASDAQ Global Market, each representing eight ordinary shares. No CUSIP number has been assigned to the Ordinary Shares.

CUSIP No. 81255T108

Name of Reporting Person:

Novo Holdings A/S

Check the Appropriate Box if a Member of Group (See Instructions):

(a)  ☐

(b)  ☐

SEC Use Only:

Citizenship or Place of Organization:

Denmark

Number of

Shares

Beneficially

Owned By

Each

Reporting

Person

With:

Sole Voting Power:

1,308,037

Shared Voting Power:

0

Sole Dispositive Power:

1,308,037

Shared Dispositive Power:

0

Aggregate Amount Beneficially Owned by Each Reporting Person:

1,308,037

Check if the Aggregate Amount in Row (9) Excludes Certain Shares:  ☐

Percent of Class Represented By Amount In Row (9):

7.06% (1)

Type of Reporting Person:

CO

Based upon 18,532,759 shares of the Issuers Common Stock outstanding as of October 30, 2018, as reported in the Issuers 10-Q filed with the Securities and Exchange Commission (the SEC) on November 6, 2018.

SeaSpine Holdings Corp

5770 Armada Drive

Carlsbad, CA 92008

Novo Holdings A/S, a Danish limited liability company, is wholly owned by Novo Nordisk Foundation (the Foundation), a Danish commercial foundation. Novo Holdings A/S is the holding company in the group of Novo companies (currently comprised of Novo Nordisk A/S, Novozymes A/S and NNIT A/S) and is responsible for managing the Foundations assets, including its financial assets. Based on the governance structure of Novo Holdings A/S and the Foundation, the Foundation is not deemed to have any beneficial ownership of the securities of the Issuer held by Novo Holdings A/S.

Tuborg Havnevej 19

2900 Hellerup, Denmark

Novo Holdings A/S:    Denmark

Common Stock

81255T108

Ownership:

(a)

Amount beneficially owned:

(b)

Percent of class:

(c)

Number of shares as to which such person has:

(i) Sole power to vote or to direct the vote:

(ii) Shared power to vote or to direct the vote:

(iii) Sole power to dispose or to direct the disposition of:

(iv) Shared power to dispose or to direct the disposition of:

Novo Holdings A/S, through its Board of Directors (the Novo Board), has the sole power to vote and dispose of the securities of the Issuer held by Novo Holdings A/S (the Novo Shares). The Novo Board, currently comprised of Lars Rebien Sorensen, Steen Riisgaard, Francis Cuss, Jean-Luc Butel, Jeppe Christiansen and Vivian Monges, may exercise voting and dispositive control over the Novo Shares only with the support of a majority of the Novo Board. As such, no individual member of the Novo Board is deemed to hold any beneficial ownership or reportable pecuniary interest in the Novo Shares.

Based upon 18,532,759 shares of the Issuers Common Stock outstanding as of October 30, 2018, as reported in the Issuers 10-Q filed with the SEC on November 6, 2018.

Ownership of Five Percent or Less of a Class:

Ownership of More Than Five Percent on Behalf of Another Person:

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person:

Identification and Classification of Members of the Group:

Notice of Dissolution of Group:

Certifications: