| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 22,970,388 | $604,810,316 | 27.44% | |
| 2. | Rubric Capital Management David Rosen | 5,750,000 | $151,397,500 | +23% | 1.81% |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 3,938,641 | $103,704,418 | 3.49% | |
| 4. | Perceptive Advisors Joseph Edelman | 3,261,850 | $85,884,511 | +57% | 1.53% |
| 5. | Siren L.L.C. Raymond Debbane | 1,680,121 | $44,237,586 | 1.32% |